| pubmed-article:9185568 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9185568 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:9185568 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:9185568 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:9185568 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:9185568 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:9185568 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:9185568 | pubmed:dateCreated | 1997-7-28 | lld:pubmed |
| pubmed-article:9185568 | pubmed:abstractText | The restriction of herpes virus latency to mammalian sensory ganglia has led to a search for tissue-specific regulatory molecules in these neurons which alter viral gene expression. We have recently shown that the POU-domain transcriptional regulator Brn-3.0 is abundantly expressed in the adult trigeminal ganglion. To begin to examine the hypothesis that Brn-3.0 might participate in the regulation of the HSV life-cycle, we used Brn-3.0 POU-domain protein as an affinity matrix, and biochemically screened the entire HSV genome for sites of Brn-3.0 binding. This screen identified several sites of the form TA/TA A T N A N TA/T, which significantly do not include the previously identified HSV octamer sequences. All of the selected sites occur in the <25% of the HSV genome which has not been assigned to open reading frames, suggesting that these sites may be transcriptional regulatory elements recognized by Brn-3.0 or another homeobox factor with similar DNA binding properties. However, these sites do not interact with Brn-3.0 with sufficiently high affinity to directly mediate transcriptional activation by Brn-3.0 alone in transfection assays. The experiments described also provide an effective general method for exhaustive screening of large viral genomes or sub-genomic fragments of eukaryotic DNA for sites of interaction with specific transcription factors. | lld:pubmed |
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| pubmed-article:9185568 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9185568 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9185568 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9185568 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9185568 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:9185568 | pubmed:author | pubmed-author:ReedG LGL | lld:pubmed |
| pubmed-article:9185568 | pubmed:author | pubmed-author:TurnerE EEE | lld:pubmed |
| pubmed-article:9185568 | pubmed:author | pubmed-author:FeldmanL TLT | lld:pubmed |
| pubmed-article:9185568 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9185568 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9185568 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:9185568 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9185568 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9185568 | pubmed:pagination | 2589-94 | lld:pubmed |
| pubmed-article:9185568 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9185568 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9185568 | pubmed:articleTitle | The POU-domain factor Brn-3.0 recognizes characteristic sites in the herpes simplex virus genome. | lld:pubmed |
| pubmed-article:9185568 | pubmed:affiliation | Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0603, USA. eturner@ucsd.edu | lld:pubmed |
| pubmed-article:9185568 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9185568 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9185568 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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