Linked Life Data

9183565

Source:http://linkedlifedata.com/resource/pubmed/id/9183565

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-8-26
pubmed:abstractText
Dimethyl sulfate (DMS; CAS No. 77-78) is a colorless, oily liquid which is used as a chemical intermediate and as a reactant in producing polyurethane resins. In this study, groups of pregnant Crl:CD BR rats were exposed, nose-only, to either 0.1, 0.7 or 1.5 ppm DMS by inhalation for 6 hr/day from Days 7 through 16 of gestation (day in which copulation plug was detected was designated Day 1G). A control group of pregnant rats was exposed simultaneously to air only. All female rats were euthanized on Day 22G and the fetuses were examined. A suppression of both food consumption and the rate of body weight gain was seen in the 0.7 and 1.5 ppm groups. No unusual clinical signs were seen in rats exposed to DMS. None of the reproductive parameters was altered in any of the groups and no statistically significant fetal effects were detected. DMS is not a developmental toxin in the rat following inhalation exposures up to 1.5 ppm during the period of major organogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-0545
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-114
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Developmental toxicity of dimethyl sulfate by inhalation in the rat.
pubmed:affiliation
E.I. DuPont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE 19714, USA.
pubmed:publicationType
Journal Article, Comparative Study