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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-7-21
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pubmed:abstractText |
We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ-induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
227
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9180214-Animals,
pubmed-meshheading:9180214-Diabetes Mellitus, Experimental,
pubmed-meshheading:9180214-Light,
pubmed-meshheading:9180214-Male,
pubmed-meshheading:9180214-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:9180214-Rats,
pubmed-meshheading:9180214-Rats, Wistar,
pubmed-meshheading:9180214-Suprachiasmatic Nucleus
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pubmed:year |
1997
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pubmed:articleTitle |
Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Science, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article
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