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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-6-23
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pubmed:abstractText |
The allergen-induced late asthmatic reaction (LAR) is associated with mucosal inflammation involving several cell types including activated T lymphocytes and eosinophils. In contrast, the early asthmatic reaction (EAR) is considered to results from rapid allergen-induced release of bronchoconstrictor mediators from IgE sensitised mast cells. Cyclosporin A has efficacy in chronic severe corticosteroid-dependent asthma and is believed to act principally by inhibiting cytokine mRNA transcription in T lymphocytes. However, it has effects on other cell types in vitro, including the inhibition of exocytosis/degranulation events in mast cells. It was therefore hypothesised that cyclosporin A would attenuate both the EAR and LAR in subjects with mild asthma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-1371491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-1530827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-1677063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-1752957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-1859063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-1875171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-1970370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-2236751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-2252260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-2433975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-2480971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-2671739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-2913891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-3106449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-3680512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-717706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-7540862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-7561691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-7697273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-7742012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-7798558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-8339804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-8349942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-8417755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-8466126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-8575571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9176537-8607370
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0040-6376
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9176537-Adult,
pubmed-meshheading:9176537-Asthma,
pubmed-meshheading:9176537-Bronchial Provocation Tests,
pubmed-meshheading:9176537-Cross-Over Studies,
pubmed-meshheading:9176537-Cyclosporine,
pubmed-meshheading:9176537-Double-Blind Method,
pubmed-meshheading:9176537-Eosinophils,
pubmed-meshheading:9176537-Female,
pubmed-meshheading:9176537-Forced Expiratory Volume,
pubmed-meshheading:9176537-Humans,
pubmed-meshheading:9176537-Hypersensitivity, Delayed,
pubmed-meshheading:9176537-Hypersensitivity, Immediate,
pubmed-meshheading:9176537-Immunosuppressive Agents,
pubmed-meshheading:9176537-Leukocyte Count,
pubmed-meshheading:9176537-Male,
pubmed-meshheading:9176537-Middle Aged
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pubmed:year |
1997
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pubmed:articleTitle |
Effect of cyclosporin A on the allergen-induced late asthmatic reaction.
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pubmed:affiliation |
Imperial College School of Medicine, National Heart and Lung Institute, London, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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