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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-6-20
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pubmed:databankReference |
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pubmed:abstractText |
Tip of herpesvirus saimiri associates with Lck and down-regulates Lck-mediated activation. We identified a novel cellular Tip-associated protein (Tap) by a yeast two-hybrid screen. Tap associated with Tip following transient expression in COS-1 cells and stable expression in human Jurkat-T cells. Expression of Tip and Tap in Jurkat-T cells induced dramatic cell aggregation. Aggregation was likely caused by the up-regulated surface expression of adhesion molecules including integrin alpha, L-selectin, ICAM-3, and H-CAM. Furthermore, NF-kappaB transcriptional factor of aggregated cells had approximately 40-fold higher activity than that of parental cells. Thus, Tap is likely to be an important cellular mediator of Tip function in T cell transformation by herpesvirus saimiri.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
571-82
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9175835-Amino Acid Sequence,
pubmed-meshheading:9175835-Animals,
pubmed-meshheading:9175835-COS Cells,
pubmed-meshheading:9175835-Cell Adhesion Molecules,
pubmed-meshheading:9175835-Cell Aggregation,
pubmed-meshheading:9175835-Cloning, Molecular,
pubmed-meshheading:9175835-DNA, Complementary,
pubmed-meshheading:9175835-Humans,
pubmed-meshheading:9175835-Jurkat Cells,
pubmed-meshheading:9175835-Molecular Sequence Data,
pubmed-meshheading:9175835-NF-kappa B,
pubmed-meshheading:9175835-Nucleocytoplasmic Transport Proteins,
pubmed-meshheading:9175835-Phosphoproteins,
pubmed-meshheading:9175835-Protein Biosynthesis,
pubmed-meshheading:9175835-Proteins,
pubmed-meshheading:9175835-RNA-Binding Proteins,
pubmed-meshheading:9175835-T-Lymphocytes,
pubmed-meshheading:9175835-Viral Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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