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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-5-13
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pubmed:abstractText |
The HIV Tat protein is a transcriptional transactivator of the HIV-1 long terminal repeat (LTR) promoter element. Its activity depends on its direct interaction with the trans-activation response (TAR) element, although TAR-independent activation by Tat has been demonstrated in different cells. Herpesviruses in general and human cytomegalovirus (HCMV) in particular are often isolated from HIV-1-infected patients and could play a role in the activation of latent HIV and in a subsequent increase in HIV replication. HCMV immediate early gene products (IE1 and IE2) are nuclear phosphoproteins that play a pivotal role in HCMV replication and have been shown to transregulate both viral and cellular gene expression. It has repeatedly been shown that HCMV IE1/IE2 can independently transactivate HIV-1 LTR. The aim of this study was to investigate IE1/IE2 transactivation of HIV-1 LTR in a CD4+ T-cell line in the absence and presence of HIV-1 Tat to establish whether IE1/IE2 can synergize with Tat.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/IE1 protein, cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/IE2 protein, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/UL115 protein, Human herpesvirus 5,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein O, cytomegalovirus
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0269-9370
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-303
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9147420-Cytomegalovirus,
pubmed-meshheading:9147420-Gene Products, tat,
pubmed-meshheading:9147420-Genes, Reporter,
pubmed-meshheading:9147420-HIV Long Terminal Repeat,
pubmed-meshheading:9147420-Humans,
pubmed-meshheading:9147420-Immediate-Early Proteins,
pubmed-meshheading:9147420-Luciferases,
pubmed-meshheading:9147420-Membrane Glycoproteins,
pubmed-meshheading:9147420-Mutagenesis, Site-Directed,
pubmed-meshheading:9147420-NF-kappa B,
pubmed-meshheading:9147420-Plasmids,
pubmed-meshheading:9147420-Sp1 Transcription Factor,
pubmed-meshheading:9147420-Trans-Activators,
pubmed-meshheading:9147420-Transcriptional Activation,
pubmed-meshheading:9147420-Transfection,
pubmed-meshheading:9147420-Viral Envelope Proteins,
pubmed-meshheading:9147420-Viral Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
TAR and Sp1-independent transactivation of HIV long terminal repeat by the Tat protein in the presence of human cytomegalovirus IE1/IE2.
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pubmed:affiliation |
Department of Clinical and Experimental Medicine, University of Bologna, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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