Linked Life Data

9129226

Source:http://linkedlifedata.com/resource/pubmed/id/9129226

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-5-13
pubmed:abstractText
Indolent, primary cutaneous T-cell lymphomas (CTCL) are characterized by hyper-proliferation of malignant T-helper cells in the skin with a favorable prognosis in the early stages. Cytotoxic T cells (CTLs) are believed to be of major importance for tumor surveillance, but there is not yet sufficient evidence for a systemic anti-tumor response in mycosis fungoides (MF). On the contrary, there are hints of systemic immunodepression. We wondered whether signs of a systemic anti-tumor response were demonstrable in peripheral blood of patients with MF and CD30+ pleomorphic T cell lymphoma. Using multiparameter flow cytometry, we investigated blood samples from 39 CTCL patients at different stages and compared them with those from patients with psoriasis, atopic dermatitis, and healthy volunteers. In CTCL patients, an elevated number of lymphocytes expressing natural killer cell markers were found, as well as considerable T-cell activation, indicated by increased percentages of T cells expressing HLA-DR, IL-2 receptor alpha-chain, and transferrin receptor. The CD8+ T cells, which were the most strongly activated T-cell subset, were of polyclonal origin, as shown by their usage of different T-cell receptor families. The enhanced expression of activation antigens was associated with an increased proportion of CD8+ T cells with high expression of the adhesion molecule LFA-1, demonstrating the capacity for migration of these cells. These CD8+ effector cells are suspected to be CTLs and may be responsible for the favorable prognosis of indolent, primary CTCL. Interestingly, a stage-dependent decrease in T-cell activation antigen expression was observed, suggesting the development of a lack in tumor surveillance in advanced MF stages. Further investigations are necessary to verify whether any of the parameters determined are of predictive value for prognosis and response to therapy in CTCL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
743-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9129226-Adult, pubmed-meshheading:9129226-Antigens, CD, pubmed-meshheading:9129226-Antigens, Differentiation, B-Lymphocyte, pubmed-meshheading:9129226-Antigens, Neoplasm, pubmed-meshheading:9129226-CD8-Positive T-Lymphocytes, pubmed-meshheading:9129226-Flow Cytometry, pubmed-meshheading:9129226-HLA-DR Antigens, pubmed-meshheading:9129226-Humans, pubmed-meshheading:9129226-Killer Cells, Natural, pubmed-meshheading:9129226-Leukocyte Count, pubmed-meshheading:9129226-Leukocytes, pubmed-meshheading:9129226-Lymphocyte Activation, pubmed-meshheading:9129226-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:9129226-Lymphocyte Subsets, pubmed-meshheading:9129226-Lymphoma, T-Cell, Cutaneous, pubmed-meshheading:9129226-Mycosis Fungoides, pubmed-meshheading:9129226-Neutrophils, pubmed-meshheading:9129226-Receptors, Interleukin-2, pubmed-meshheading:9129226-Receptors, Transferrin, pubmed-meshheading:9129226-T-Lymphocytes
pubmed:year
1997
pubmed:articleTitle
Enhanced expression of T-cell activation and natural killer cell antigens indicates systemic anti-tumor response in early primary cutaneous T-cell lymphoma.
pubmed:affiliation
Department of Dermatology, Medical School Charité, Humboldt UniversityBerlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't