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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-3-14
|
| pubmed:abstractText |
To clarify the relation between macrophage and myofibroblast involvement in various myocardial diseases, the authors investigated the kinetics of these cells in the healing (scar tissue formation) following isoproterenol-induced myocardial injury in rats. Alpha-smooth muscle actin (alpha-SMA) expressing myofibroblasts were seen at the border of the affected area and appeared in the greatest numbers on days 3-7 post-injection, followed by a gradual decrease by day 35. The peak on day 3 was consistent with the timing of the highest proliferative activity of myofibroblasts. The number of ED1-positive macrophages began to increase as early as day 1, reaching a peak on day 3 within the injured myocardium. The expansion of ED1-positive macrophages preceded an increased number of alpha-SMA-positive myofibroblasts suggesting that myofibroblast proliferation and activation may be mediated by factors released by ED1-positive macrophages in response to myocardial injury. The number of ED2-positive tissue-fixed, resident macrophages gradually, increased from day 3 post-injection, and peaked on day 14, but the number of ED2-positive macrophages was consistently fewer than that of ED1-positive macrophages during the 35 day-observation period after the injection. The labelling index of the ED2-positive cells was maximal on day 14, indicative of local proliferation of resident macrophages. In the healing process after myocardial injury, ED1-positive macrophages increase markedly in the early stages: ED2-positive macrophages appear later.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0945-6317
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
430
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
63-9
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9037317-Animals,
pubmed-meshheading:9037317-Fibroblasts,
pubmed-meshheading:9037317-Heart,
pubmed-meshheading:9037317-Heart Injuries,
pubmed-meshheading:9037317-Immunohistochemistry,
pubmed-meshheading:9037317-Isoproterenol,
pubmed-meshheading:9037317-Macrophages,
pubmed-meshheading:9037317-Male,
pubmed-meshheading:9037317-Myocardium,
pubmed-meshheading:9037317-Rats,
pubmed-meshheading:9037317-Rats, Sprague-Dawley,
pubmed-meshheading:9037317-Wound Healing
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
In vivo responses of macrophages and myofibroblasts in the healing following isoproterenol-induced myocardial injury in rats.
|
| pubmed:affiliation |
Laboratory of Toxicologic Pathology, Kanebo Limited, Osaka, Japan.
|
| pubmed:publicationType |
Journal Article
|