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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-2-4
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pubmed:abstractText |
Philadelphia cells are human chronic myelogenous leukemia (CML) cells that contain the BCR/ABL oncogene (a fusion of the BCR and ABL genes). Selective eradication of these cells in vitro can be achieved by combined treatment with antisense phosphorothioate oligodeoxynucleotides ([S]ODNs) specifically targeted to this oncogene (bcr/abl [S]ODNs) and a suboptimal (for use as a single agent) dose of mafosfamide (the in vitro active form of cyclophosphamide).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
124-33
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8998181-Animals,
pubmed-meshheading:8998181-Antineoplastic Agents,
pubmed-meshheading:8998181-Apoptosis,
pubmed-meshheading:8998181-Blotting, Western,
pubmed-meshheading:8998181-Bone Marrow,
pubmed-meshheading:8998181-Bone Marrow Cells,
pubmed-meshheading:8998181-Cyclophosphamide,
pubmed-meshheading:8998181-DNA Probes,
pubmed-meshheading:8998181-Flow Cytometry,
pubmed-meshheading:8998181-Fusion Proteins, bcr-abl,
pubmed-meshheading:8998181-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8998181-Humans,
pubmed-meshheading:8998181-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:8998181-Mice,
pubmed-meshheading:8998181-Mice, SCID,
pubmed-meshheading:8998181-Oligonucleotides, Antisense,
pubmed-meshheading:8998181-Philadelphia Chromosome,
pubmed-meshheading:8998181-Polymerase Chain Reaction,
pubmed-meshheading:8998181-Survival Analysis,
pubmed-meshheading:8998181-Thionucleotides,
pubmed-meshheading:8998181-Treatment Outcome,
pubmed-meshheading:8998181-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides.
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pubmed:affiliation |
Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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