| pubmed-article:8990120 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8990120 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8990120 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:8990120 | lifeskim:mentions | umls-concept:C1265498 | lld:lifeskim |
| pubmed-article:8990120 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:8990120 | lifeskim:mentions | umls-concept:C0039082 | lld:lifeskim |
| pubmed-article:8990120 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:8990120 | pubmed:issue | 6612 | lld:pubmed |
| pubmed-article:8990120 | pubmed:dateCreated | 1997-1-30 | lld:pubmed |
| pubmed-article:8990120 | pubmed:abstractText | Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone receptor (MC1-R), thus explaining the inhibitory effect of agouti on eumelanin pigment synthesis. The agouti peptide is also an antagonist of the hypothalamic melanocortin-4 receptor (MC4-R). To test the hypothesis that agouti causes obesity by antagonism of hypothalamic melanocortin receptors, we identified cyclic melanocortin analogues that are potent agonists or antagonists of the neural MC3 (refs 11, 12) and MC4 receptors. Intracerebroventricular administration of the agonist, MTII, inhibited feeding in four models of hyperphagia: fasted C57BL/6J, ob/ob, and A(Y) mice, and mice injected with neuropeptide Y. Co-administration of the specific melanocortin antagonist and agouti-mimetic SHU9119 completely blocked this inhibition. Furthermore, administration of SHU9119 significantly enhanced nocturnal feeding, or feeding stimulated by a prior fast. Our data show that melanocortinergic neurons exert a tonic inhibition of feeding behaviour. Chronic disruption of this inhibitory signal is a likely explanation of the agouti obesity syndrome. | lld:pubmed |
| pubmed-article:8990120 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8990120 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8990120 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8990120 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8990120 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8990120 | pubmed:author | pubmed-author:HrubyV JVJ | lld:pubmed |
| pubmed-article:8990120 | pubmed:author | pubmed-author:FanWW | lld:pubmed |
| pubmed-article:8990120 | pubmed:author | pubmed-author:ConeR DRD | lld:pubmed |
| pubmed-article:8990120 | pubmed:author | pubmed-author:KestersonR... | lld:pubmed |
| pubmed-article:8990120 | pubmed:author | pubmed-author:BostonB ABA | lld:pubmed |
| pubmed-article:8990120 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8990120 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:8990120 | pubmed:volume | 385 | lld:pubmed |
| pubmed-article:8990120 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8990120 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8990120 | pubmed:pagination | 165-8 | lld:pubmed |
| pubmed-article:8990120 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:meshHeading | pubmed-meshheading:8990120-... | lld:pubmed |
| pubmed-article:8990120 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:8990120 | pubmed:articleTitle | Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. | lld:pubmed |
| pubmed-article:8990120 | pubmed:affiliation | The Vollum Institute for Advanced Biomedical Research, Portland, Oregon 97201, USA. | lld:pubmed |
| pubmed-article:8990120 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8990120 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8990120 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16846 | entrezgene:pubmed | pubmed-article:8990120 | lld:entrezgene |
| entrez-gene:17201 | entrezgene:pubmed | pubmed-article:8990120 | lld:entrezgene |
| entrez-gene:17202 | entrezgene:pubmed | pubmed-article:8990120 | lld:entrezgene |
| entrez-gene:50518 | entrezgene:pubmed | pubmed-article:8990120 | lld:entrezgene |
| entrez-gene:109648 | entrezgene:pubmed | pubmed-article:8990120 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8990120 | lld:pubmed |
