| pubmed-article:8987738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C0010837 | lld:lifeskim |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C0071163 | lld:lifeskim |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:8987738 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:8987738 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8987738 | pubmed:dateCreated | 1997-2-4 | lld:pubmed |
| pubmed-article:8987738 | pubmed:abstractText | Pituitary adenylate cyclase-activating polypeptides (PACAP-27 and PACAP-38) are neuropeptides of the vasoactive intestinal polypeptide (VIP)/secretin/glucagon family. PACAP receptors are expressed in different brain regions, including cerebellum. We used primary culture of rat cerebellar granule neurons to study the effect of PACAP-38 on apoptosis induced by potassium deprivation. We demonstrated that PACAP-38 increased survival of cerebellar neurons in a dose-dependent manner by decreasing the extent of apoptosis estimated by DNA fragmentation. PACAP-38 induced activation of the extracellular signal-regulated kinase (ERK)-type of mitogen-activated protein (MAP) kinase through a cAMP-dependent pathway. PD98059, an inhibitor of MEK (MAP kinase kinase), completely abolished the antiapoptotic effect of PACAP-38, suggesting that MAP kinase pathway activation is necessary for PACAP-38 action. | lld:pubmed |
| pubmed-article:8987738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8987738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8987738 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8987738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8987738 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8987738 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:8987738 | pubmed:author | pubmed-author:BockaertJJ | lld:pubmed |
| pubmed-article:8987738 | pubmed:author | pubmed-author:VillalbaMM | lld:pubmed |
| pubmed-article:8987738 | pubmed:author | pubmed-author:JournotLL | lld:pubmed |
| pubmed-article:8987738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8987738 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8987738 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:8987738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8987738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8987738 | pubmed:pagination | 83-90 | lld:pubmed |
| pubmed-article:8987738 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8987738 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:8987738 | pubmed:articleTitle | Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. | lld:pubmed |
| pubmed-article:8987738 | pubmed:affiliation | Centre National de la Recherche Scientifique (CNRS), Unité Propre de Recherche 9023, Centre CNRS-Institut National de la Santé et de la Recherche Médicale de Pharmacologie-Endocrinologie, F-34094 Montpellier Cedex 05, France. | lld:pubmed |
| pubmed-article:8987738 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8987738 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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