| pubmed-article:8985195 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8985195 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:8985195 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:8985195 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8985195 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:8985195 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8985195 | lifeskim:mentions | umls-concept:C0242656 | lld:lifeskim |
| pubmed-article:8985195 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:8985195 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8985195 | pubmed:dateCreated | 1997-1-27 | lld:pubmed |
| pubmed-article:8985195 | pubmed:abstractText | Cytokine mRNA expression and stimulus-induced cytokines were examined in peripheral blood mononuclear cells in 62 human immunodeficiency virus (HIV)-infected children and uninfected controls. Compared with that in controls, constitutive mRNA expression in patients was increased for tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-10 and decreased for IL-12; it was undetectable for IL-2 and IL-4 in both patients and controls. Stimulus-induced secretion of TNF-alpha, IFN-gamma, IL-12, and IL-4 was less than that in controls; IL-10 secretion was similar. There was no increase in stimulus-induced or constitutive IL-4 or IL-10 in children with severe immunologic deficit compared with controls. A higher stimulus-induced IL-10 secretion and a lower constitutive TNF-alpha mRNA were associated with a slower rate of disease progression, and TNF-alpha mRNA expression correlated with lower plasma HIV RNA. Thus, constitutive cytokine mRNA expression differs from stimulus-induced cytokine responses. The dominant defect in HIV-infected children appears to be one of reduced type 1 cytokines, predominantly IL-2. | lld:pubmed |
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| pubmed-article:8985195 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8985195 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8985195 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8985195 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8985195 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:8985195 | pubmed:author | pubmed-author:PahwaSS | lld:pubmed |
| pubmed-article:8985195 | pubmed:author | pubmed-author:ThamRR | lld:pubmed |
| pubmed-article:8985195 | pubmed:author | pubmed-author:HuRR | lld:pubmed |
| pubmed-article:8985195 | pubmed:author | pubmed-author:RomanoJJ | lld:pubmed |
| pubmed-article:8985195 | pubmed:author | pubmed-author:SheikhSS | lld:pubmed |
| pubmed-article:8985195 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:8985195 | pubmed:author | pubmed-author:OyaizuNN | lld:pubmed |
| pubmed-article:8985195 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8985195 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:8985195 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8985195 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8985195 | pubmed:pagination | 47-56 | lld:pubmed |
| pubmed-article:8985195 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8985195 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:8985195 | pubmed:articleTitle | Cytokine pattern in relation to disease progression in human immunodeficiency virus-infected children. | lld:pubmed |
| pubmed-article:8985195 | pubmed:affiliation | Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030, USA. | lld:pubmed |
| pubmed-article:8985195 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8985195 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8985195 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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