| pubmed-article:8977707 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8977707 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:8977707 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:8977707 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:8977707 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:8977707 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:8977707 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8977707 | pubmed:dateCreated | 1997-1-9 | lld:pubmed |
| pubmed-article:8977707 | pubmed:abstractText | Glycoprotein IIb-IIIa (integrin alpha IIb beta3) is an adhesive receptor involved in platelet aggregation and adhesion to the extracellular matrix. Previous studies showed the presence of IIb-IIIa-like glycoproteins on cells of melanoma cell lines and on cells of lymph node metastases. This study evaluates the presence of glycoprotein IIb-IIIa subunits on cells of primary cutaneous malignant melanomas with (n = 4) and without (n = 9) metastases over a period of 6 years and on naevus cells (n = 4). Monoclonal antibodies directed against the subunits of the glycoprotein IIb-IIIa receptor were used on paraffin-embedded sections and evaluated by means of immunohistochemistry. The glycoprotein IIb subunit was exclusively present on cells of metastatic melanomas. It was not found on non-metastatic melanomas or benign melanocytes. These data favour the role of the integrin receptor glycoprotein IIb-IIIa in the metastatic behaviour of malignant melanomas. | lld:pubmed |
| pubmed-article:8977707 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8977707 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8977707 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8977707 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8977707 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8977707 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8977707 | pubmed:issn | 0007-0963 | lld:pubmed |
| pubmed-article:8977707 | pubmed:author | pubmed-author:RingJJ | lld:pubmed |
| pubmed-article:8977707 | pubmed:author | pubmed-author:WorretW IWI | lld:pubmed |
| pubmed-article:8977707 | pubmed:author | pubmed-author:GawazMM | lld:pubmed |
| pubmed-article:8977707 | pubmed:author | pubmed-author:PuerschelW... | lld:pubmed |
| pubmed-article:8977707 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8977707 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:8977707 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8977707 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8977707 | pubmed:pagination | 883-7 | lld:pubmed |
| pubmed-article:8977707 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:meshHeading | pubmed-meshheading:8977707-... | lld:pubmed |
| pubmed-article:8977707 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8977707 | pubmed:articleTitle | Immunoreactivity of glycoprotein IIb is present in metastasized but not in non-metastasized primary malignant melanoma. | lld:pubmed |
| pubmed-article:8977707 | pubmed:affiliation | Department of Dermatology, Technical University, Munich, Germany. | lld:pubmed |
| pubmed-article:8977707 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8977707 | pubmed:publicationType | Comparative Study | lld:pubmed |
