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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-1-23
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pubmed:abstractText |
Glucocorticoids have been used to create experimental polycystic kidney disease in rodents and to induce cysts in embryonic kidneys cultures. In addition, the plasma corticosterone levels are higher in a heritable murine model of polycystic kidney disease, cpk mice, in the first postnatal week. Previously, we had shown that the 11beta-hydroxysteroid dehydrogenase-1 (11betaHSD-1) gene is down-regulated in the cpk mice in a coordinated pattern with the Ke 6 gene. In this study, we measured the level of 11betaHSD-1 activity in kidney and liver tissues of cpk homozygote mice and found a reduction in its activity only in the kidney, not in the liver. The activity of the 11betaHSD-1 enzyme appears to be tightly correlated to the level of Ke 6 protein in these tissues. We discuss the possibility that the activity of the 11betaHSD-1 enzyme may be regulated by the Ke 6 enzyme. Ke 6 gene expression has been located to the outer stripe region of rodent kidneys, which is the same region of expression as that for the 11betaHSD-1 gene. These results suggest that down-regulation of the Ke 6 gene may lead to elevated corticosterone levels, mediated through an inhibition of 11betaHSD-1 activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5581-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8940387-11-beta-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:8940387-Animals,
pubmed-meshheading:8940387-Female,
pubmed-meshheading:8940387-Fluorescent Antibody Technique,
pubmed-meshheading:8940387-Gene Expression Regulation,
pubmed-meshheading:8940387-Histocompatibility Antigens,
pubmed-meshheading:8940387-Homozygote,
pubmed-meshheading:8940387-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:8940387-Isoenzymes,
pubmed-meshheading:8940387-Kidney,
pubmed-meshheading:8940387-Male,
pubmed-meshheading:8940387-Mice,
pubmed-meshheading:8940387-Mice, Inbred C57BL,
pubmed-meshheading:8940387-Microsomes,
pubmed-meshheading:8940387-NADP,
pubmed-meshheading:8940387-Oxidoreductases,
pubmed-meshheading:8940387-Polycystic Kidney Diseases,
pubmed-meshheading:8940387-RNA, Messenger,
pubmed-meshheading:8940387-Rats
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pubmed:year |
1996
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pubmed:articleTitle |
Aberrant 11beta-hydroxysteroid dehydrogenase-1 activity in the cpk mouse: implications for regulation by the Ke 6 gene.
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pubmed:affiliation |
Department of Medicine, Children's Hospital, Boston, Massachusetts 02115, USA. aziz@a1.tch.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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