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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-10-29
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pubmed:abstractText |
In the present report, we investigated the potential involvement of imidazoline I1 and I2 binding sites in the inhibition of the Ca(2+)-activated K+ channel (Gardos channel) by clotrimazole in human red cells. Ca(2+)-activated 86Rb influx was inhibited by clotrimazole and efaroxan but not by the imidazoline binding site ligands clonidine, moxonidine, cirazoline and idazoxan (100 microM). Binding studies with [3H]idazoxan and [3H]p-aminoclonidine did not reveal the expression of I1 and I2 binding sites in erythrocytes. These data indicate that the effects of clotrimazole and efaroxan on the erythrocyte Ca(2+)-activated K+ channel may be mediated by a 'non-I1/non-I2' binding site.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8925867-Adrenergic alpha-Antagonists,
pubmed-meshheading:8925867-Benzofurans,
pubmed-meshheading:8925867-Binding Sites,
pubmed-meshheading:8925867-Calcium,
pubmed-meshheading:8925867-Clotrimazole,
pubmed-meshheading:8925867-Dose-Response Relationship, Drug,
pubmed-meshheading:8925867-Erythrocytes,
pubmed-meshheading:8925867-Humans,
pubmed-meshheading:8925867-Imidazoles,
pubmed-meshheading:8925867-Potassium Channels
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pubmed:year |
1996
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pubmed:articleTitle |
Clotrimazole and efaroxan inhibit red cell Gardos channel independently of imidazoline I1 and I2 binding sites.
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pubmed:affiliation |
INSERM U388, Institut Louis Bugnard, CHU Rangueil, Toulouse, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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