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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-2-7
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pubmed:abstractText |
The effect of gamma-hydroxybutyric acid (GHB) on the excitatory postsynaptic potential (EPSP) evoked in thalamocortical neurones of the rat dorsal lateral geniculate nucleus and ventrobasal thalamus was investigated in vitro. GHB (0.1-5 mM) dose-dependently and reversibly decreased (36-78%) the amplitude of the sensory EPSP. This effect of GHB was blocked by the GABAB receptor antagonist CGP 35348 (1 mM). NCS 382 (1-3 mM), a putative GHB receptor antagonist, did not antagonise but weakly potentiated both the GHB- and baclofen-mediated decrease of the EPSP amplitude.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Anesthesia,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Baclofen,
http://linkedlifedata.com/resource/pubmed/chemical/Benzocycloheptenes,
http://linkedlifedata.com/resource/pubmed/chemical/Bicuculline,
http://linkedlifedata.com/resource/pubmed/chemical/CGP 35348,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA-B Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/NCS 382,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-B,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Oxybate
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
216
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8904798-Adjuvants, Anesthesia,
pubmed-meshheading:8904798-Animals,
pubmed-meshheading:8904798-Anticonvulsants,
pubmed-meshheading:8904798-Baclofen,
pubmed-meshheading:8904798-Benzocycloheptenes,
pubmed-meshheading:8904798-Bicuculline,
pubmed-meshheading:8904798-Dose-Response Relationship, Drug,
pubmed-meshheading:8904798-Electrophysiology,
pubmed-meshheading:8904798-GABA Agonists,
pubmed-meshheading:8904798-GABA Antagonists,
pubmed-meshheading:8904798-GABA-B Receptor Agonists,
pubmed-meshheading:8904798-Geniculate Bodies,
pubmed-meshheading:8904798-Male,
pubmed-meshheading:8904798-Neurons, Afferent,
pubmed-meshheading:8904798-Organophosphorus Compounds,
pubmed-meshheading:8904798-Presynaptic Terminals,
pubmed-meshheading:8904798-Rats,
pubmed-meshheading:8904798-Rats, Wistar,
pubmed-meshheading:8904798-Receptors, GABA-B,
pubmed-meshheading:8904798-Sodium Oxybate,
pubmed-meshheading:8904798-Synaptic Transmission
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pubmed:year |
1996
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pubmed:articleTitle |
Gamma-hydroxybutyric acid decreases thalamic sensory excitatory postsynaptic potentials by an action on presynaptic GABAB receptors.
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pubmed:affiliation |
Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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