Linked Life Data

8896139

Source:http://linkedlifedata.com/resource/pubmed/id/8896139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1997-1-30
pubmed:abstractText
Some clinical trials involving subjects with the human immunodeficiency virus (HIV) allow a subject to change treatment when a marker of disease progression, for example, the CD4 cell count, falls below a defined threshold. Although the change does not involve a randomized control, there is considerable interest in assessing whether it might have beneficial effects on the marker levels. However, the effects of regression to the mean will confound a simple analysis of the repeated measurements obtained before and after the cross-over. In this paper, we present a likelihood-based methodology for this problem and apply it to assess a cross-over from placebo to treatment with a drug, zidovudine, in a cohort of HIV infected individuals. This cross-over occurred when a subject first had two successive CD4 cell counts below 500/mm3. As well as providing important information about the effects of introducing zidovudine among subjects with early asymptomatic HIV infection, this paper illustrates methods for verifying model assumptions, an important component of such analyses which are necessarily model dependent.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0277-6715
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2053-67
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Analysis of uncontrolled treatment changes in HIV clinical trails.
pubmed:affiliation
Research Department, United Network for Organ Sharing, Richmond, VA 23225, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Research Support, Non-U.S. Gov't