Linked Life Data

8822039

Source:http://linkedlifedata.com/resource/pubmed/id/8822039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-12-10
pubmed:abstractText
To examine the importance of preanalytical factors on the sample concentration of morphine, morphine-3-glucuronide and morphine-6-glucuronide, blood samples were drawn in sets of four from 21 patients who were given morphine due to chronic pain or as premedication prior to surgery. Three different sampling tubes, different combinations of incubation temperature and time, and different temperatures during centrifugation were used and compared to reference standard treatment of blood samples using analysis of variance. Blood samples taken in EDTA tubes produced significantly higher (4.8%) concentrations of morphine compared with the reference levels obtained in heparin glass tubes. Incubation of blood samples at body temperature resulted in significantly higher (4.4%) morphine levels compared to reference levels. None of the other conditions studied influenced the sample concentrations of morphine significantly. The levels of the metabolites were not significantly affected under any of the tested conditions. Even if the preanalytical factors investigated in this study had little influence on the results, a standardised procedure is recommended for handling of blood samples for analysis of morphine and its metabolites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0901-9928
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
82-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The influence of preanalytical factors on concentrations of morphine and metabolites in patients receiving morphine.
pubmed:affiliation
Department of Anaesthesiology, University of Lund, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't