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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1996-9-30
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pubmed:abstractText |
The degree of serum cholesterol lowering by up to almost maximal inhibition of cholesterol absorption was tested during neomycin and neomycin + sitostanol treatment in six hypercholesterolemic men. Neomycin decreased cholesterol absorption efficiency by 49% and the combination by 79%, and serum cholesterol level by 27% and 36%, respectively. The correlation between the absorption percentage and low density lipoprotein (LDL) cholesterol was significant (r = 0.510), and the regression equation (y = 0.04x + 2.59) suggested that the mean LDL cholesterol content would be about 2.5 mmol/l at zero cholesterol absorption. In conclusion, in hypercholesterolemic subjects, the lowering of LDL cholesterol appears to be limited to a low normal range only by almost totally inhibiting cholesterol absorption.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Neomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Sitosterols,
http://linkedlifedata.com/resource/pubmed/chemical/stigmastanol
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8801876-Absorption,
pubmed-meshheading:8801876-Anticholesteremic Agents,
pubmed-meshheading:8801876-Cholesterol,
pubmed-meshheading:8801876-Cholesterol, LDL,
pubmed-meshheading:8801876-Humans,
pubmed-meshheading:8801876-Hypercholesterolemia,
pubmed-meshheading:8801876-Male,
pubmed-meshheading:8801876-Middle Aged,
pubmed-meshheading:8801876-Neomycin,
pubmed-meshheading:8801876-Sitosterols
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pubmed:year |
1995
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pubmed:articleTitle |
The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level.
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pubmed:affiliation |
Second Department of Medicine, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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