|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1996-9-17
|
|
pubmed:abstractText |
A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnamoyl]glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 microg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 microg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 microg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0163-3864
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
541-3
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8778246-Aloe,
pubmed-meshheading:8778246-Animals,
pubmed-meshheading:8778246-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:8778246-Chromatography, High Pressure Liquid,
pubmed-meshheading:8778246-Chromones,
pubmed-meshheading:8778246-Croton Oil,
pubmed-meshheading:8778246-Ear, External,
pubmed-meshheading:8778246-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:8778246-Inflammation,
pubmed-meshheading:8778246-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8778246-Male,
pubmed-meshheading:8778246-Mass Spectrometry,
pubmed-meshheading:8778246-Mice,
pubmed-meshheading:8778246-Mice, Inbred BALB C,
pubmed-meshheading:8778246-Plants, Medicinal,
pubmed-meshheading:8778246-Spectrophotometry, Ultraviolet
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Antiinflammatory C-glucosyl chromone from Aloe barbadensis.
|
|
pubmed:affiliation |
Department of Pharmacology, Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284-7760, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
