pubmed-article:8769097 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8769097 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
pubmed-article:8769097 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:8769097 | lifeskim:mentions | umls-concept:C2700303 | lld:lifeskim |
pubmed-article:8769097 | lifeskim:mentions | umls-concept:C0385463 | lld:lifeskim |
pubmed-article:8769097 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
pubmed-article:8769097 | lifeskim:mentions | umls-concept:C0599155 | lld:lifeskim |
pubmed-article:8769097 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
pubmed-article:8769097 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:8769097 | pubmed:dateCreated | 1996-9-25 | lld:pubmed |
pubmed-article:8769097 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:abstractText | We cloned the full-length rat leptin receptor (Ob-R) isoform complementary DNAs (cDNAs) and examined the gene expression in rats. We also identified a mutation in Ob-R in Zucker fatty (fa/fa) rats. Three alternatively spliced isoforms (Ob-Ra, Ob-Rb, and Ob-Re) have been identified, which are closely related to the gp130 signal-transduction component of class I cytokine receptors. Rat Ob-Ra and Ob-Rb were single transmembrane proteins, which differ in the C-terminal amino acid sequences. On the other hand, Ob-Re had no transmembrane domain and was a soluble form of the receptor. Reverse transcription-polymerase chain reaction analysis revealed that Ob-R isoform messenger RNAs (mRNAs) are expressed in a wide variety of rat tissues in tissue-specific manners. A missense mutation (an A to C conversion at nucleotide position 806) was found in the extracellular domain of all the isoforms in Zucker fatty (fa/fa) rats, which resulted in an amino acid change from Gln to Pro at + 269 (the Gln269Pro mutation). These Ob-R isoform mRNAs were present in the brain from Zucker fatty (fa/fa) rats at comparable amounts to those in their lean littermates. The present study provides new insight into the molecular mechanisms for Ob-R. | lld:pubmed |
pubmed-article:8769097 | pubmed:language | eng | lld:pubmed |
pubmed-article:8769097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8769097 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8769097 | pubmed:month | Aug | lld:pubmed |
pubmed-article:8769097 | pubmed:issn | 0006-291X | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:OkazakiTT | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:OgawaYY | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:NakaiMM | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:MoriKK | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:HosodaKK | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:TamuraNN | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:TakayaKK | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:SatohNN | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:MasuzakiHH | lld:pubmed |
pubmed-article:8769097 | pubmed:author | pubmed-author:IsseNN | lld:pubmed |
pubmed-article:8769097 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8769097 | pubmed:day | 5 | lld:pubmed |
pubmed-article:8769097 | pubmed:volume | 225 | lld:pubmed |
pubmed-article:8769097 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8769097 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8769097 | pubmed:pagination | 75-83 | lld:pubmed |
pubmed-article:8769097 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:meshHeading | pubmed-meshheading:8769097-... | lld:pubmed |
pubmed-article:8769097 | pubmed:year | 1996 | lld:pubmed |
pubmed-article:8769097 | pubmed:articleTitle | Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats. | lld:pubmed |
pubmed-article:8769097 | pubmed:affiliation | Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan. | lld:pubmed |
pubmed-article:8769097 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8769097 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:8769097 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:16847 | entrezgene:pubmed | pubmed-article:8769097 | lld:entrezgene |
entrez-gene:24536 | entrezgene:pubmed | pubmed-article:8769097 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769097 | lld:pubmed |