| pubmed-article:8759320 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8759320 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:8759320 | lifeskim:mentions | umls-concept:C2699488 | lld:lifeskim |
| pubmed-article:8759320 | lifeskim:mentions | umls-concept:C1617068 | lld:lifeskim |
| pubmed-article:8759320 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8759320 | pubmed:dateCreated | 1996-9-19 | lld:pubmed |
| pubmed-article:8759320 | pubmed:abstractText | The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus is a causative agent of the toxic shock syndrome disease. It belongs to a family of proteins known as superantigens that cross-link major histocompatibility class II molecules and T-cell receptors leading to the activation of a substantial number of T cells. The crystal structure of this protein has been refined to 2.07 A with an Rcryst value of 20.4% for 51,240 reflections. The final model contains three molecules in the asymmetric unit with good stereochemistry and a root-mean-square deviation of 0.009 A and 1.63 from ideality for bond lengths and bond angles, respectively. The overall fold is considerably similar to that of other known microbial superantigens (staphylococcal enterotoxins). However, a detailed structural analysis shows that toxic shock syndrome toxin-1 lacks several structural features that affect its specificity for V beta elements of the T-cell receptor and also its recognition by major histocompatibility class II molecules. | lld:pubmed |
| pubmed-article:8759320 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8759320 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8759320 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8759320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8759320 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8759320 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8759320 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:8759320 | pubmed:author | pubmed-author:AcharyaK RKR | lld:pubmed |
| pubmed-article:8759320 | pubmed:author | pubmed-author:PapageorgiouA... | lld:pubmed |
| pubmed-article:8759320 | pubmed:author | pubmed-author:LeonidasD DDD | lld:pubmed |
| pubmed-article:8759320 | pubmed:author | pubmed-author:TranterH SHS | lld:pubmed |
| pubmed-article:8759320 | pubmed:author | pubmed-author:BrehmR DRD | lld:pubmed |
| pubmed-article:8759320 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8759320 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:8759320 | pubmed:volume | 260 | lld:pubmed |
| pubmed-article:8759320 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8759320 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8759320 | pubmed:pagination | 553-69 | lld:pubmed |
| pubmed-article:8759320 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8759320 | pubmed:meshHeading | pubmed-meshheading:8759320-... | lld:pubmed |
| pubmed-article:8759320 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8759320 | pubmed:articleTitle | The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution. | lld:pubmed |
| pubmed-article:8759320 | pubmed:affiliation | School of Biology and Biochemistry, University of Bath, Claverton Down, UK. | lld:pubmed |
| pubmed-article:8759320 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8759320 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8759320 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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