Linked Life Data

8759296

Source:http://linkedlifedata.com/resource/pubmed/id/8759296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-10-8
pubmed:abstractText
Ducks (Anatidae Family, Anseriform order) are divided in two genera: Pekin duck (Anasplatyrhynchos genus) and Muscovy duck (Cairina moschata genus) and differ for their number of liver insulin receptors (despite rather similar plasma insulin levels). The possibility that the presence of different endogenous insulins account for the difference in insulin receptor number between the two duck species led us to purify, sequence and characterize the binding properties of Muscovy duck insulin. The sequence of Muscovy duck insulin (measured mass: 5729.11) was identical to that described in two other species from the Anseriforme order: Pekin duck or goose. The binding affinity of Muscovy duck insulin for rat liver insulin receptors (either membrane bound or solubilized receptors) was lower than that of porcine insulin (0.3), which most likely accounts for the low biological potency of Pekin duck insulin previously described. In contrast, liver receptors from chicken and both duck species exhibited the same affinity for duck and porcine insulin suggesting the presence of specific changes in the structure of binding sites of bird liver insulin receptors. The decrease in the number of insulin receptors in Muscovy duck liver is not therefore the consequence of a change at the level of the insulin molecule itself. As discussed, among bird insulins, the hypoactive "duck type" insulin would have appeared after the hyperactive "chicken type" insulin during the evolution of Aves.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1096-4959
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-26
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Isolation and characterization of Muscovy (Cairna moschata) duck insulin.
pubmed:affiliation
Endocrinologie De La Croissance Et Du Métabolisme, Station De Recherches Avicoles, INRA, Nouzilly, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't