| pubmed-article:8746800 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C0039841 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C1148573 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:8746800 | lifeskim:mentions | umls-concept:C0205812 | lld:lifeskim |
| pubmed-article:8746800 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8746800 | pubmed:dateCreated | 1997-1-17 | lld:pubmed |
| pubmed-article:8746800 | pubmed:abstractText | Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA sites) were evaluated using Quantitative Receptor Autoradiography in rat brain following 14 days of treatment with the central thiamine antagonist pyrithiamine. Compared to pair-fed controls, brains of symptomatic thiamine-deficient animals contained significantly fewer NMDA-displaceable binding sites in cerebral cortex, medial septum and hippocampus. It has been suggested that NMDA-receptor mediated glutamate excitotoxicity plays a role in the pathogenesis of neuronal loss in thiamine deficiency. If such is the case, the selective loss of NMDA binding sites in cerebral cortex and hippocampus offers a possible explanation for the relative nonvulnerability of these brain regions to pyrithiamine-induced thiamine deficiency. [3H]quisqualate (AMPA) binding sites were unchanged in all brain regions of pyrithiamine-treated rats whereas [3H]kainate sites were significantly reduced in density in medial and lateral thalamus. The decline in these binding sites may be due to neuronal loss in pyrithiamine-induced thiamine deficiency. Alterations of glutamatergic synaptic function involving both NMDA and kainate receptor subclasses could contribute to the pathogenesis of neurological dysfunction in Wernicke's Encephalopathy in humans. | lld:pubmed |
| pubmed-article:8746800 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8746800 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8746800 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8746800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8746800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8746800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8746800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8746800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8746800 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8746800 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8746800 | pubmed:issn | 0364-3190 | lld:pubmed |
| pubmed-article:8746800 | pubmed:author | pubmed-author:PetersonCC | lld:pubmed |
| pubmed-article:8746800 | pubmed:author | pubmed-author:ButterworthR... | lld:pubmed |
| pubmed-article:8746800 | pubmed:author | pubmed-author:LavoieJJ | lld:pubmed |
| pubmed-article:8746800 | pubmed:author | pubmed-author:HérouxMM | lld:pubmed |
| pubmed-article:8746800 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8746800 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:8746800 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8746800 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8746800 | pubmed:pagination | 1155-60 | lld:pubmed |
| pubmed-article:8746800 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:meshHeading | pubmed-meshheading:8746800-... | lld:pubmed |
| pubmed-article:8746800 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8746800 | pubmed:articleTitle | Loss of [3H]kainate and of NMDA-displaceable [3H]glutamate binding sites in brain in thiamine deficiency: results of a quantitative autoradiographic study. | lld:pubmed |
| pubmed-article:8746800 | pubmed:affiliation | Dept of Gerontology, University of Southern California, Los Angeles, USA. | lld:pubmed |
| pubmed-article:8746800 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8746800 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
