|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1996-8-14
|
|
pubmed:abstractText |
We have investigated the mechanism of interferon (IFN) induction in peripheral blood mononuclear cells by HIV-1(IIIB)-infected H9 cells or by recombinant gp120. A monoclonal antibody specific for the galactosylsphingosinyl moiety in galactocerebrosides and sulfatides inhibited IFN induction in a dose-dependent manner. Furthermore, exogenous sulfatides inhibited with an ID50 of approximately 1 microM, whereas galactocerebrosides were not inhibitory at 40 times higher concentrations. These studies suggest that sulfate containing galactolipids such as sulfatides on responder cells may be part of the gp120-membrane complex that initiates the induction of IFN. A partial homology of an epitope on the V3 loop of gp 120 with a previously suggested binding domain for sulfated glycoconjugates supports this conclusion.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0042-6822
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
221
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
113-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8661419-Amino Acid Sequence,
pubmed-meshheading:8661419-Antibodies, Monoclonal,
pubmed-meshheading:8661419-Cells, Cultured,
pubmed-meshheading:8661419-Glycolipids,
pubmed-meshheading:8661419-HIV Envelope Protein gp120,
pubmed-meshheading:8661419-HIV-1,
pubmed-meshheading:8661419-Humans,
pubmed-meshheading:8661419-Interferon-alpha,
pubmed-meshheading:8661419-Molecular Sequence Data,
pubmed-meshheading:8661419-Peptides,
pubmed-meshheading:8661419-Psychosine,
pubmed-meshheading:8661419-Sulfoglycosphingolipids,
pubmed-meshheading:8661419-Tumor Cells, Cultured
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids.
|
|
pubmed:affiliation |
Medical College of Wisconsin, Milwaukee 53226, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
