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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-7-16
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pubmed:abstractText |
A novel recombinant histamine-releasing factor (rHFR), which stimulates secretion from a subpopulation of human basophils that express a particular type of immunoglobulin E (IgE) or IgE+, was found to induce interleukin-4 (IL-4) production from cells isolated from these same donors. The secretion of IL-4 protein induced by rHRF significantly correlated with histamine release and the amount of protein generated, and the kinetics were identical to those caused by anti-IgE activation. Furthermore, the ability of rHRF to induce IL-4 protein production from cells not normally responsive to this protein was transferred by passive sensitization with plasma containing IgE+ antibody. That this novel protein stimulates both mediator release and the secretion of IL-4 protein from human basophils suggests a prominent role for this molecule in allergic disease.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-10779279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-1354235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-1371130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-1680337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-1700998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-1708690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-1890258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2410512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2419428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2419443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2423445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2439589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2468620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2469728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-2473400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-3195836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-49201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-6195189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-7507512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-7510984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-7519213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-7542803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-7687630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-8144899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-8276835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8642270-8436904
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/translationally controlled tumor...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1265-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8642270-Basophils,
pubmed-meshheading:8642270-Cells, Cultured,
pubmed-meshheading:8642270-Chemokine CCL2,
pubmed-meshheading:8642270-Cloning, Molecular,
pubmed-meshheading:8642270-DNA, Complementary,
pubmed-meshheading:8642270-Histamine Release,
pubmed-meshheading:8642270-Humans,
pubmed-meshheading:8642270-Immunization, Passive,
pubmed-meshheading:8642270-Immunoglobulin E,
pubmed-meshheading:8642270-Interleukin-3,
pubmed-meshheading:8642270-Interleukin-4,
pubmed-meshheading:8642270-Kinetics,
pubmed-meshheading:8642270-Lymphokines,
pubmed-meshheading:8642270-Recombinant Proteins,
pubmed-meshheading:8642270-Tumor Markers, Biological
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pubmed:year |
1996
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pubmed:articleTitle |
An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils.
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pubmed:affiliation |
The Johns Hopkins Asthma and Allergy Center, Department of Medicine, Baltimore, Maryland 22124, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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