|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1996-7-17
|
|
pubmed:abstractText |
In hypertension with cardiac hypertrophy, the specific contributions to increased production of the cardiac natriuretic peptides (NP) atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) by load and the hypertrophic process are not known. In the present work we determine ANF and BNP synthesis and secretion in the aortic-banded rat treated with dosage schedules of the ACE inhibitor ramipril that result in the prevention or regression of both hypertension and hypertrophy (high dosage) or in the prevention or regression of hypertrophy alone with persistent hypertension (low dosage). Myosin heavy chain (MHC) isoform switch was studied as an indicator of ventricular cardiocyte hypertrophy as well as the levels of collagen III mRNA as a measure of changes in extracellular matrix.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0009-7322
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
93
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2059-67
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8640983-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:8640983-Animals,
pubmed-meshheading:8640983-Antihypertensive Agents,
pubmed-meshheading:8640983-Aorta,
pubmed-meshheading:8640983-Atrial Natriuretic Factor,
pubmed-meshheading:8640983-Base Sequence,
pubmed-meshheading:8640983-Body Weight,
pubmed-meshheading:8640983-Constriction,
pubmed-meshheading:8640983-Hemodynamics,
pubmed-meshheading:8640983-Hypertension,
pubmed-meshheading:8640983-Hypertrophy, Left Ventricular,
pubmed-meshheading:8640983-Male,
pubmed-meshheading:8640983-Molecular Sequence Data,
pubmed-meshheading:8640983-Myocardium,
pubmed-meshheading:8640983-Natriuretic Peptide, Brain,
pubmed-meshheading:8640983-Nerve Tissue Proteins,
pubmed-meshheading:8640983-Organ Size,
pubmed-meshheading:8640983-Ramipril,
pubmed-meshheading:8640983-Rats,
pubmed-meshheading:8640983-Rats, Sprague-Dawley,
pubmed-meshheading:8640983-Renin
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Evidence for load-dependent and load-independent determinants of cardiac natriuretic peptide production.
|
|
pubmed:affiliation |
University of Ottawa Heart Institute, Ottawa Civic Hospital, Ontario, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
