| pubmed-article:8618665 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8618665 | lifeskim:mentions | umls-concept:C0497327 | lld:lifeskim |
| pubmed-article:8618665 | lifeskim:mentions | umls-concept:C0003595 | lld:lifeskim |
| pubmed-article:8618665 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:8618665 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8618665 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8618665 | pubmed:dateCreated | 1996-6-13 | lld:pubmed |
| pubmed-article:8618665 | pubmed:abstractText | Apolipoprotein E type 4 allele (apoE epsilon4) is associated with Alzheimer's disease (AD) in the late-onset familial form and in sporadic cases, but the age-associated risk in a randomly sampled elderly population is not established. We examined the association of apoE epsilon4 with AD and other dementias (mainly multi-infarct or dementia following stroke) in 1,030 persons aged 71 to 100 years in the population-based Framingham Study cohort. Kaplan-Meier survival analysis revealed that 55% of the apoE epsilon4/epsilon4 homozygotes developed AD by age 80, whereas 27% of apoE epsilon3/epsilon4 heterozygotes developed AD by age 85, and 9% of those without a 4 allele developed AD by age 85 years. In comparison with persons without a 4 allele, the risk ration for AD was 3.7 (95% CI = 1.9 to 7.5) for apoE epsilon3/epsilon4 heterozygotes and 30.1 (95% CI = 10.7 to 84.4) for apoE epsilon4 homozygotes. ApoE epsilon2 (2/2, 2/3, or 2/4 genotypes) was associated with an absence of AD. One-half (n=21) of the 43 AD patients were either homozygous or heterozygous for apoE epsilon4. We found evidence for an association of apoE epsilon4 with other dementia, primarily multi-infarct dementia and stroke. The risk ratio was 2.3 (95% CI = 0.9 to 6.1) for non-AD dementias among persons with apoE epsilon3/epsilon4. Although the apoE epsilon4 allele is a potent risk factor for AD and may be associated with other forms of dementia, most apoE epsilon4 carriers do not develop dementia, and about one-half of AD is not apoE epsilon4 associated. The low positive predictive value of this marker (0.10) suggest that use of apoE genotyping as a screening test for AD is not supported. | lld:pubmed |
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| pubmed-article:8618665 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8618665 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618665 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8618665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618665 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8618665 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8618665 | pubmed:issn | 0028-3878 | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:CobbJ LJL | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:WhiteR FRF | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:SchaeferE JEJ | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:WolfP APA | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:MyersR HRH | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:WilsonP WPW | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:PaiP NPN | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:D'AgostinoRR | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:OrdovasJ MJM | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:EspinoAA | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:KnoefelJ EJE | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:BeiserAA | lld:pubmed |
| pubmed-article:8618665 | pubmed:author | pubmed-author:McNultyK AKA | lld:pubmed |
| pubmed-article:8618665 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8618665 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:8618665 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8618665 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8618665 | pubmed:pagination | 673-7 | lld:pubmed |
| pubmed-article:8618665 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8618665 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8618665 | pubmed:articleTitle | Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. | lld:pubmed |
| pubmed-article:8618665 | pubmed:affiliation | Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA. | lld:pubmed |
| pubmed-article:8618665 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8618665 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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