Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-6-13
|
| pubmed:abstractText |
Apolipoprotein E type 4 allele (apoE epsilon4) is associated with Alzheimer's disease (AD) in the late-onset familial form and in sporadic cases, but the age-associated risk in a randomly sampled elderly population is not established. We examined the association of apoE epsilon4 with AD and other dementias (mainly multi-infarct or dementia following stroke) in 1,030 persons aged 71 to 100 years in the population-based Framingham Study cohort. Kaplan-Meier survival analysis revealed that 55% of the apoE epsilon4/epsilon4 homozygotes developed AD by age 80, whereas 27% of apoE epsilon3/epsilon4 heterozygotes developed AD by age 85, and 9% of those without a 4 allele developed AD by age 85 years. In comparison with persons without a 4 allele, the risk ration for AD was 3.7 (95% CI = 1.9 to 7.5) for apoE epsilon3/epsilon4 heterozygotes and 30.1 (95% CI = 10.7 to 84.4) for apoE epsilon4 homozygotes. ApoE epsilon2 (2/2, 2/3, or 2/4 genotypes) was associated with an absence of AD. One-half (n=21) of the 43 AD patients were either homozygous or heterozygous for apoE epsilon4. We found evidence for an association of apoE epsilon4 with other dementia, primarily multi-infarct dementia and stroke. The risk ratio was 2.3 (95% CI = 0.9 to 6.1) for non-AD dementias among persons with apoE epsilon3/epsilon4. Although the apoE epsilon4 allele is a potent risk factor for AD and may be associated with other forms of dementia, most apoE epsilon4 carriers do not develop dementia, and about one-half of AD is not apoE epsilon4 associated. The low positive predictive value of this marker (0.10) suggest that use of apoE genotyping as a screening test for AD is not supported.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0028-3878
|
| pubmed:author |
pubmed-author:BeiserAA,
pubmed-author:CobbJ LJL,
pubmed-author:D'AgostinoRR,
pubmed-author:EspinoAA,
pubmed-author:KnoefelJ EJE,
pubmed-author:McNultyK AKA,
pubmed-author:MyersR HRH,
pubmed-author:OrdovasJ MJM,
pubmed-author:PaiP NPN,
pubmed-author:SchaeferE JEJ,
pubmed-author:WhiteR FRF,
pubmed-author:WilsonP WPW,
pubmed-author:WolfP APA
|
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
673-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8618665-Adult,
pubmed-meshheading:8618665-Aged,
pubmed-meshheading:8618665-Aged, 80 and over,
pubmed-meshheading:8618665-Alleles,
pubmed-meshheading:8618665-Alzheimer Disease,
pubmed-meshheading:8618665-Apolipoprotein E4,
pubmed-meshheading:8618665-Apolipoproteins E,
pubmed-meshheading:8618665-Base Sequence,
pubmed-meshheading:8618665-Cohort Studies,
pubmed-meshheading:8618665-Dementia,
pubmed-meshheading:8618665-Female,
pubmed-meshheading:8618665-Humans,
pubmed-meshheading:8618665-Incidence,
pubmed-meshheading:8618665-Longitudinal Studies,
pubmed-meshheading:8618665-Male,
pubmed-meshheading:8618665-Middle Aged,
pubmed-meshheading:8618665-Molecular Probes,
pubmed-meshheading:8618665-Molecular Sequence Data,
pubmed-meshheading:8618665-Odds Ratio,
pubmed-meshheading:8618665-Sensitivity and Specificity
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study.
|
| pubmed:affiliation |
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|