Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1996-4-24
|
pubmed:abstractText |
To compare the diagnostic usefulness as markers of hepatocellular carcinoma (HCC) of alpha1-antitrypsin, C-reactive protein, and alpha1-acid glycoprotein (all determined by nephelometric methods), we studied 132 subjects (74 male, 58 female): 43 had mild chronic liver disease, 32 cirrhosis, 24 HCC; 33 were controls. A total of 29.2% of the patients with HCC had alpha1-acid glycoprotein > 100 mg/dl, 75.0% had alpha1-antitrypsin > 220 mg/dl, 70.8% had C-reactive protein > 5 mg/L. In cirrhotics, frequencies were 3.1, 50.0 and 59.4%, respectively; in patients with mild chronic liver disease, 14.0, 11.6, and 32.6% (chi2 12.3, p < 0.01; chi2 47.3, p < 0.0001; chi2 38.0, p < 0.0001, respectively). alpha1-fetoprotein performed better than all acute-phase proteins. We conclude that, due to their low specificity and/or sensitivity, none of the three acute-phase reactants tested can be recommended for diagnostic use as biological markers of HCC in Western patients.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0735-7907
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
103-8
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:8597894-Acute-Phase Proteins,
pubmed-meshheading:8597894-Adult,
pubmed-meshheading:8597894-Aged,
pubmed-meshheading:8597894-C-Reactive Protein,
pubmed-meshheading:8597894-Carcinoma, Hepatocellular,
pubmed-meshheading:8597894-Diagnosis, Differential,
pubmed-meshheading:8597894-Female,
pubmed-meshheading:8597894-Humans,
pubmed-meshheading:8597894-Liver Cirrhosis,
pubmed-meshheading:8597894-Liver Neoplasms,
pubmed-meshheading:8597894-Male,
pubmed-meshheading:8597894-Middle Aged,
pubmed-meshheading:8597894-Orosomucoid,
pubmed-meshheading:8597894-alpha 1-Antitrypsin
|
pubmed:year |
1996
|
pubmed:articleTitle |
Diagnostic usefulness of acute-phase protein measurement in hepatocellular carcinoma.
|
pubmed:affiliation |
Cattedra di Medicina Interna, Medical School, University of Udine, Udine, Italy.
|
pubmed:publicationType |
Journal Article
|