|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6568
|
|
pubmed:dateCreated |
1996-3-25
|
|
pubmed:abstractText |
Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficiency in adipose tissue and liver produces hyperinsulinaemia, impaired glucose tolerance and resistance to insulin in vivo. Insulin resistance affects glucose-transporter activity and recruitment, counterregulation of lipolysis, and activation of glycogen synthase, all of which are cardinal responses to insulin. G ialpha2 deficiency increases protein-tyrosine phosphatase activity and attenuates insulin-stimulated tyrosine phosphorylation of IRS (insulin-receptor substrate 1) in vivo. G ialpha2 deficiency creates a model for insulin resistance characteristic of noninsulin-dependent diabetes mellitus (NIDDM), implicating G ialpha2 as a positive regulator of insulin action.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Slc2a4 protein, mouse
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
29
|
|
pubmed:volume |
379
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
840-4
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:8587610-Adipose Tissue,
pubmed-meshheading:8587610-Animals,
pubmed-meshheading:8587610-Biological Transport,
pubmed-meshheading:8587610-Blood Glucose,
pubmed-meshheading:8587610-Diabetes Mellitus, Type 2,
pubmed-meshheading:8587610-Disease Models, Animal,
pubmed-meshheading:8587610-GTP-Binding Proteins,
pubmed-meshheading:8587610-Glucose Transporter Type 4,
pubmed-meshheading:8587610-Glycogen Synthase,
pubmed-meshheading:8587610-Hyperinsulinism,
pubmed-meshheading:8587610-Insulin,
pubmed-meshheading:8587610-Insulin Receptor Substrate Proteins,
pubmed-meshheading:8587610-Insulin Resistance,
pubmed-meshheading:8587610-Lipolysis,
pubmed-meshheading:8587610-Liver,
pubmed-meshheading:8587610-Mice,
pubmed-meshheading:8587610-Mice, Transgenic,
pubmed-meshheading:8587610-Monosaccharide Transport Proteins,
pubmed-meshheading:8587610-Muscle Proteins,
pubmed-meshheading:8587610-Phosphoproteins,
pubmed-meshheading:8587610-RNA, Antisense
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Insulin action impaired by deficiency of the G-protein subunit G ialpha2.
|
|
pubmed:affiliation |
Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Program, University Medical Center, SUNY/Stony Brook, New York 11794-8651, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
