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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1996-3-21
|
| pubmed:abstractText |
Invasive endoscopic procedures such as total colonoscopy result in a better patient acceptance, the less discomfort they cause. Therefore a premedication for total colonoscopy is often required. In a prospective, double-blind, placebo-controlled clinical study of 132 patients examined by one experienced endoscopist we compared two premedication schedules: midazolam (mean 5.2 mg i.v.) versus midazolam (mean 4.8 mg) plus pethidin (50 mg). We found that the combination midazolam plus pethidin provides a deeper and more reliable sedation and analgesia than midazolam alone. The combination of both drugs caused also more anterograde amnesia. It was also shown, that the endoscopist scored a higher degree of patient's pain during the examination than the patient did himself. No more negative side-effects such as decrease of arterial partial pressure of oxygen or cardiopulmonary complications were found using the combination of both drugs; they provided to be safe without added risk of hypoxia. Thus, the combination of both drugs can be given as premedication for total colonoscopy.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0044-2771
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
704-8
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading |
pubmed-meshheading:8585252-Adolescent,
pubmed-meshheading:8585252-Adult,
pubmed-meshheading:8585252-Aged,
pubmed-meshheading:8585252-Analgesics, Opioid,
pubmed-meshheading:8585252-Colonoscopy,
pubmed-meshheading:8585252-Conscious Sedation,
pubmed-meshheading:8585252-Dose-Response Relationship, Drug,
pubmed-meshheading:8585252-Double-Blind Method,
pubmed-meshheading:8585252-Drug Therapy, Combination,
pubmed-meshheading:8585252-Female,
pubmed-meshheading:8585252-Humans,
pubmed-meshheading:8585252-Hypnotics and Sedatives,
pubmed-meshheading:8585252-Male,
pubmed-meshheading:8585252-Meperidine,
pubmed-meshheading:8585252-Midazolam,
pubmed-meshheading:8585252-Middle Aged,
pubmed-meshheading:8585252-Pain Measurement,
pubmed-meshheading:8585252-Patient Acceptance of Health Care,
pubmed-meshheading:8585252-Premedication,
pubmed-meshheading:8585252-Prospective Studies
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
[Acceptability of high colonoscopy using different premedication--a comparison of the effect of midazolam versus midazolam and pethidine from the viewpoint of the patient and the physician].
|
| pubmed:affiliation |
IV. Medizinische Klinik, Schwerpunkt Gastroenterologie, des Klinikums Mannheim, Universität Heidelberg, Mannheim.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
English Abstract,
Randomized Controlled Trial
|