|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1979-6-11
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pubmed:abstractText |
5-Azacytidine (5-AzaCR) reduced significantly the levels of ribosomal 28S and 18S RNAs in the cytoplasm of uninfected and simian virus 40 (SV40)-infected BSC-1 cells. The percent inhibition of ribosomal RNAs was correlated to both the dose of AzaCR and the time of exposure. In SV40-infected cultures treated with 200 microgram/ml AzaCR, a portion of the total cytoplasmic radioactivity was observed to sediment as 19S and 16S by sucrose gradient analysis. The 19S and 16S peaks represented in part the viral-specific RNA species. This result was due to the drastic reduction (70--75%) of ribosomal RNAs in the cytoplasm of infected cultures.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0300-5526
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
191-5
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:85613-Animals,
pubmed-meshheading:85613-Azacitidine,
pubmed-meshheading:85613-Cell Line,
pubmed-meshheading:85613-Haplorhini,
pubmed-meshheading:85613-Kidney,
pubmed-meshheading:85613-RNA,
pubmed-meshheading:85613-RNA, Messenger,
pubmed-meshheading:85613-RNA, Ribosomal,
pubmed-meshheading:85613-RNA, Viral,
pubmed-meshheading:85613-Simian virus 40
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|
pubmed:year |
1979
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|
pubmed:articleTitle |
Effect of azacytidine in SV40-infected BSC-1 cells.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
