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pubmed-article:8558852pubmed:abstractTextEukaryotic translation initiation factor EIF-4E is a key component in the regulation of translational efficiency of MRNAs and its increased expression may accelerate cell growth and division. EIF-4E has the potential to transform rat embryo fibroblast cells by cooperation with v-Myc or adenovirus E1A. Our previous study showed that a variety of tumor cells examined exhibited elevated levels of eIF-4E gene expression. Thus it is thought that overexpression of EIF-4E can result in aberrant growth and cell transformation.lld:pubmed
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pubmed-article:8558852pubmed:articleTitleAbundant expression of translation initiation factor EIF-4E in post-meiotic germ cells of the rat testis.lld:pubmed
pubmed-article:8558852pubmed:affiliationBiophysics Division, National Cancer Center Research Institute, Tokyo, Japan.lld:pubmed
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