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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-2-27
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pubmed:databankReference |
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pubmed:abstractText |
Eukaryotic translation initiation factor EIF-4E is a key component in the regulation of translational efficiency of MRNAs and its increased expression may accelerate cell growth and division. EIF-4E has the potential to transform rat embryo fibroblast cells by cooperation with v-Myc or adenovirus E1A. Our previous study showed that a variety of tumor cells examined exhibited elevated levels of eIF-4E gene expression. Thus it is thought that overexpression of EIF-4E can result in aberrant growth and cell transformation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0023-6837
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
890-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8558852-Amino Acid Sequence,
pubmed-meshheading:8558852-Animals,
pubmed-meshheading:8558852-Base Sequence,
pubmed-meshheading:8558852-Cloning, Molecular,
pubmed-meshheading:8558852-DNA, Complementary,
pubmed-meshheading:8558852-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:8558852-Gene Expression Regulation,
pubmed-meshheading:8558852-Male,
pubmed-meshheading:8558852-Meiosis,
pubmed-meshheading:8558852-Molecular Sequence Data,
pubmed-meshheading:8558852-Peptide Initiation Factors,
pubmed-meshheading:8558852-Phosphorylation,
pubmed-meshheading:8558852-RNA, Messenger,
pubmed-meshheading:8558852-Rats,
pubmed-meshheading:8558852-Rats, Sprague-Dawley,
pubmed-meshheading:8558852-Spermatogenesis,
pubmed-meshheading:8558852-Spermatozoa,
pubmed-meshheading:8558852-Testis
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pubmed:year |
1995
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pubmed:articleTitle |
Abundant expression of translation initiation factor EIF-4E in post-meiotic germ cells of the rat testis.
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pubmed:affiliation |
Biophysics Division, National Cancer Center Research Institute, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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