Linked Life Data

8553539

Source:http://linkedlifedata.com/resource/pubmed/id/8553539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-2-16
pubmed:abstractText
The importance of antibody and CD8+ cells in resolution of murine rotavirus (EDIM) infection and protection against reinfection was examined with two strains of B-cell-deficient mice. Following inoculation of one strain (JHD), rotavirus infection was resolved within days, but when later reinoculated with EDIM, these mice again shed rotavirus. Thus, effector mechanisms other than antibody resolved viral shedding in JHD mice but were insufficient to prevent reinfection. EDIM shedding in another B-cell-deficient mouse strain (microMT) diminished but was not fully resolved 93 days after the initial infection, thus demonstrating that antibody could also be important in resolution of rotavirus infection. When depleted of CD8+ cells by monoclonal antibody treatment before EDIM inoculation, JHD mice were unable to resolve shedding. Even though microMT mice did not fully resolve their initial infection, depletion of CD8+ cells 49 days after initial inoculation resulted in a burst of shedding. Thus, CD8+ cells were involved in resolution of the initial EDIM infection in both strains of B-cell-deficient mice. Finally, when microMT mice were depleted of CD8+ cells before the initial EDIM infection, gradual resolution of rotavirus shedding was still observed, suggesting a third effector mechanism was also involved in resolution of rotavirus infection in mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
214
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-97
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Effector functions of antibody and CD8+ cells in resolution of rotavirus infection and protection against reinfection in mice.
pubmed:affiliation
Division of Clinical Virology, James N. Gamble Institute of Medical Research, Cincinnati, Ohio 45219, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.