|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1977-6-22
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|
pubmed:abstractText |
In urethane-anaesthetised rats, the administration of the specific histamine H2-receptor antagonist metiamide intracerebroventricularly (i.c.v.) raised the blood pressure and increased the heart rate. Metiamide (i.c.v.) antagonised the hypotensive effect of clonidine (i.c.v.) in an apparently competitive manner. 4-Methylhistamine i.c.v. did not significantly change the blood pressure. The results are consistent with the concept that the hypotensive effect of clonidine is at least partly due to a stimulation of cerebral H2-receptors. The existence of cerebral H2-receptors mediating hypotensive effects is supported by the hypertensive effect of metiamide but not by the lack of hypotensive effects of 4-methylhistamine.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0014-2999
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
42
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
299-302
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|
pubmed:dateRevised |
2009-10-27
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|
pubmed:meshHeading |
pubmed-meshheading:852501-Animals,
pubmed-meshheading:852501-Blood Pressure,
pubmed-meshheading:852501-Clonidine,
pubmed-meshheading:852501-Depression, Chemical,
pubmed-meshheading:852501-Heart Rate,
pubmed-meshheading:852501-Male,
pubmed-meshheading:852501-Methylhistamines,
pubmed-meshheading:852501-Metiamide,
pubmed-meshheading:852501-Rats,
pubmed-meshheading:852501-Receptors, Histamine,
pubmed-meshheading:852501-Receptors, Histamine H2,
pubmed-meshheading:852501-Time Factors
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|
pubmed:year |
1977
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|
pubmed:articleTitle |
Further evidence for central histamine H2-receptor involvement in the hypotensive effect of clonidine in the rat.
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pubmed:publicationType |
Journal Article
|
