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rdf:type |
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lifeskim:mentions |
umls-concept:C0004827,
umls-concept:C0014467,
umls-concept:C0017262,
umls-concept:C0035647,
umls-concept:C0035696,
umls-concept:C0035820,
umls-concept:C0040649,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C1333662,
umls-concept:C1337112,
umls-concept:C2911684
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pubmed:issue |
12
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pubmed:dateCreated |
1993-7-14
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pubmed:abstractText |
The expression of the hematopoietic transcription factors GATA-1, GATA-2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant. The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Erythroid-Specific DNA-Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GATA2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GATA3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3234-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8507862-Base Sequence,
pubmed-meshheading:8507862-Basophils,
pubmed-meshheading:8507862-Blotting, Northern,
pubmed-meshheading:8507862-Butyric Acid,
pubmed-meshheading:8507862-Butyric Acids,
pubmed-meshheading:8507862-Cell Line,
pubmed-meshheading:8507862-DNA-Binding Proteins,
pubmed-meshheading:8507862-Eosinophils,
pubmed-meshheading:8507862-Erythroid-Specific DNA-Binding Factors,
pubmed-meshheading:8507862-GATA1 Transcription Factor,
pubmed-meshheading:8507862-GATA2 Transcription Factor,
pubmed-meshheading:8507862-GATA3 Transcription Factor,
pubmed-meshheading:8507862-Gene Expression,
pubmed-meshheading:8507862-HeLa Cells,
pubmed-meshheading:8507862-Humans,
pubmed-meshheading:8507862-Interleukin-5,
pubmed-meshheading:8507862-Molecular Sequence Data,
pubmed-meshheading:8507862-RNA, Messenger,
pubmed-meshheading:8507862-Trans-Activators,
pubmed-meshheading:8507862-Transcription, Genetic,
pubmed-meshheading:8507862-Transcription Factors
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pubmed:year |
1993
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pubmed:articleTitle |
Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.
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pubmed:affiliation |
Division of Hematology, Children's Hospital, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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