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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5 Pt 1
|
| pubmed:dateCreated |
1993-6-22
|
| pubmed:abstractText |
To determine the tissue localization of insulin resistance in type 1 diabetic patients, whole body and regional glucose uptake rates were determined under euglycemic hyperinsulinemic conditions. Leg, arm, and heart glucose uptake rates were measured using positron emission tomography-derived 2-deoxy-2-[18F]-fluoro-D-glucose kinetics and the three-compartment model described by Sokoloff et al. (L. Sokoloff, M. Reivich, C. Kennedy, M.C. DesRosiers, C.S. Patlak, K.D. Pettigrew, O. Sakurada, and M. Shinohara. J. Neurochem. 28: 897-916, 1977) in eight type 1 diabetic patients and eight matched normal subjects. Whole body glucose uptake was quantitated by the euglycemic insulin clamp technique. Whole body glucose uptake was approximately 31% lower in the diabetic patients (P < 0.01) than in the normal subjects, thus confirming the presence of whole body insulin resistance. The rate of glucose uptake was approximately 45% lower in leg muscle when measured in the femoral region (55 +/- 7 vs. 102 +/- 13 mumol.kg muscle-1.min-1, diabetic patients vs. normal subjects, P < 0.05) and approximately 27% lower in the arm muscles (66 +/- 4 vs. 90 +/- 13 mumol.kg muscle-1.min-1, respectively, P < 0.05), whereas no difference was observed in heart glucose uptake [789 +/- 80 vs. 763 +/- 58 mumol.kg muscle-1.min-1 not significant (NS)]. Whole body glucose uptake correlated with glucose uptake in femoral (r = 0.93, P < 0.005) and arm muscles (r = 0.66, P < 0.05) but not with glucose uptake in the heart (r = 0.04, NS). We conclude that insulin resistance in type 1 diabetic patients is localized to skeletal muscle, whereas heart glucose uptake is unaffected.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorodeoxyglucose F18,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin
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| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0002-9513
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
264
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
E756-62
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:8498497-Adult,
pubmed-meshheading:8498497-Blood Glucose,
pubmed-meshheading:8498497-C-Peptide,
pubmed-meshheading:8498497-Deoxyglucose,
pubmed-meshheading:8498497-Diabetes Mellitus, Type 1,
pubmed-meshheading:8498497-Fluorine Radioisotopes,
pubmed-meshheading:8498497-Fluorodeoxyglucose F18,
pubmed-meshheading:8498497-Glucose,
pubmed-meshheading:8498497-Glucose Clamp Technique,
pubmed-meshheading:8498497-Heart,
pubmed-meshheading:8498497-Hemoglobin A, Glycosylated,
pubmed-meshheading:8498497-Humans,
pubmed-meshheading:8498497-Infusions, Intravenous,
pubmed-meshheading:8498497-Insulin,
pubmed-meshheading:8498497-Insulin Resistance,
pubmed-meshheading:8498497-Muscles,
pubmed-meshheading:8498497-Myocardium,
pubmed-meshheading:8498497-Organ Specificity,
pubmed-meshheading:8498497-Reference Values,
pubmed-meshheading:8498497-Tomography, Emission-Computed
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| pubmed:year |
1993
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| pubmed:articleTitle |
Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes.
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| pubmed:affiliation |
Department of Medicine, Turku Medical Cyclotron-Positron Emission Tomography Center, University of Turku, Finland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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