rdf:type |
|
lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0029266,
umls-concept:C0162745,
umls-concept:C0164371,
umls-concept:C0166027,
umls-concept:C1334706,
umls-concept:C1373200,
umls-concept:C1520397,
umls-concept:C1546465,
umls-concept:C1704332,
umls-concept:C1705175,
umls-concept:C1705176,
umls-concept:C1705177,
umls-concept:C1705178,
umls-concept:C1882348
|
pubmed:issue |
1
|
pubmed:dateCreated |
1993-6-4
|
pubmed:abstractText |
A cluster of metalloproteinase genes, stromelysin, fibroblast collagenase, and stromelysin 2 together with the anonymous DNA marker D11S385, was mapped using pulsed-field gel electrophoresis to a 135-kb region of chromosome 11q22-q23. The physical proximity of these markers was subsequently confirmed using two YAC clones, and their relative order was established as stromelysin 2-collagenase-stromelysin-D11S385. The pattern of marker representation in a panel of radiation-reduced chromosome 11 hybrids suggests that the metalloproteinase gene/D11S385 cluster is orientated with STMY2 closest to the centromere.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0888-7543
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
289-91
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8486377-Animals,
pubmed-meshheading:8486377-Base Sequence,
pubmed-meshheading:8486377-Chromosomes, Human, Pair 11,
pubmed-meshheading:8486377-Collagenases,
pubmed-meshheading:8486377-Cricetinae,
pubmed-meshheading:8486377-DNA,
pubmed-meshheading:8486377-DNA Probes,
pubmed-meshheading:8486377-Genetic Markers,
pubmed-meshheading:8486377-Glycoproteins,
pubmed-meshheading:8486377-Humans,
pubmed-meshheading:8486377-Hybrid Cells,
pubmed-meshheading:8486377-Matrix Metalloproteinase 10,
pubmed-meshheading:8486377-Matrix Metalloproteinase 3,
pubmed-meshheading:8486377-Metalloendopeptidases,
pubmed-meshheading:8486377-Molecular Sequence Data,
pubmed-meshheading:8486377-Multigene Family
|
pubmed:year |
1993
|
pubmed:articleTitle |
The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23.
|
pubmed:affiliation |
Department of Cancer Studies, Medical School, University of Birmingham, United Kingdom.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|