Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-3-23
pubmed:abstractText
The transport of two model peptides across confluent monolayers of human colon adenocarcinoma (Caco-2) cells was studied. In the case of AcPhe(NMePhe)2NH2, transport in the apical to basolateral direction was increased with increasing peptide concentration in the apical compartment. Transport was also increased in the presence of verapamil. In contrast, the flux of AcPheNH2 was neither concentration dependent nor affected by verapamil. Further, in the presence of verapamil, transport in the basolateral to apical direction was showed for AcPhe(NMePhe)2NH2 and again unchanged for AcPheNH2. These results are consistent with the presence of a saturable, apically polarized transport system in Caco-2 cells which serves to hinder transport in the apical to basolateral direction, increase flux in the basolateral to apical direction and shows substrate specificity for these model peptides.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
190
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
760-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells.
pubmed:affiliation
Drug Delivery Systems Research, Upjohn Laboratories, Upjohn Company, Kalamazoo, MI 49001.
pubmed:publicationType
Journal Article, In Vitro