| pubmed-article:8422989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8422989 | lifeskim:mentions | umls-concept:C1442823 | lld:lifeskim |
| pubmed-article:8422989 | lifeskim:mentions | umls-concept:C1442824 | lld:lifeskim |
| pubmed-article:8422989 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:8422989 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:8422989 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8422989 | lifeskim:mentions | umls-concept:C1883676 | lld:lifeskim |
| pubmed-article:8422989 | lifeskim:mentions | umls-concept:C0733688 | lld:lifeskim |
| pubmed-article:8422989 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8422989 | pubmed:dateCreated | 1993-2-25 | lld:pubmed |
| pubmed-article:8422989 | pubmed:abstractText | Transcriptional regulation by the ubiquitous human POU homeo domain protein Oct-1 and the related B-cell protein Oct-2 is a model for understanding how proteins that recognize the same regulatory site elicit different programs of gene transcription. Here, we describe a mechanism for differential promoter activation whereby only Oct-1, through selective corecruitment with the herpesvirus trans-activator VP16, acquires the ability to stimulate transcription from a TAATGARAT-containing site that responds to neither Oct-1 nor Oct-2 alone. To measure differential in vivo activation by human Oct-1 and Oct-2 in response to VP16, we have developed a transient assay in murine NIH-3T3 cells. Surprisingly, murine Oct-1 associates with VP16 much less effectively than its human counterpart, most likely because the murine Oct-1 homeo domain differs at four positions from the human Oct-1 homeo domain. The murine cell transient assay shows directly that human Oct-1, but not human Oct-2, can respond to VP16 in vivo. The Oct-1 DNA-binding POU domain is sufficient and the Oct-1 homeo domain is critical for this response, because an Oct-1 POU domain containing the Oct-2 homeo domain fails to respond to the VP16-induced positive control of transcription. Thus, by selective homeo domain interaction and corecruitment to an otherwise silent regulatory element, VP16 expands the repertoire of sites responsive to Oct-1 without affecting the activity of its close relative Oct-2. | lld:pubmed |
| pubmed-article:8422989 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8422989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8422989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8422989 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8422989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8422989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8422989 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8422989 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:8422989 | pubmed:author | pubmed-author:TanakaMM | lld:pubmed |
| pubmed-article:8422989 | pubmed:author | pubmed-author:SternSS | lld:pubmed |
| pubmed-article:8422989 | pubmed:author | pubmed-author:HerrWW | lld:pubmed |
| pubmed-article:8422989 | pubmed:author | pubmed-author:ClearyM AMA | lld:pubmed |
| pubmed-article:8422989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8422989 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:8422989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8422989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8422989 | pubmed:pagination | 72-83 | lld:pubmed |
| pubmed-article:8422989 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8422989 | pubmed:meshHeading | pubmed-meshheading:8422989-... | lld:pubmed |
| pubmed-article:8422989 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8422989 | pubmed:articleTitle | Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. | lld:pubmed |
| pubmed-article:8422989 | pubmed:affiliation | Cold Spring Harbor Laboratory, New York 11724. | lld:pubmed |
| pubmed-article:8422989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8422989 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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