| pubmed-article:8413180 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C0243043 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8413180 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:8413180 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8413180 | pubmed:dateCreated | 1993-11-1 | lld:pubmed |
| pubmed-article:8413180 | pubmed:abstractText | The MSI3 gene was isolated as a multicopy suppressor of the heat shock-sensitive phenotype of the ira1 mutation, which causes hyperactivation of the RAS-cAMP pathway. Overexpression of MSI3 also suppresses the heat shock-sensitive phenotype of the bcy1 mutant. Determination of the DNA sequence of MSI3 revealed that MSI3 can encode a 77.4 kDa protein related to the HSP70 family. The amino acid sequence of Msi3p is about 30% identical to that of the Ssa1p of Saccharomyces cerevisiae. This contrasts with the finding that members of the HSP70 family generally show at least 50% amino acid identity. The consensus nucleotide sequence of the heat shock element (HSE) was found in the upstream region of MSI3. Moreover, the steady-state levels of the MSI3 mRNA and protein were increased upon heat shock. These results indicate that the MSI3 gene encodes a novel HSP70-like heat shock protein. Disruption of the MSI3 gene was associated with a temperature sensitive growth phenotype but unexpectedly, thermotolerance was enhanced in the disruptant. | lld:pubmed |
| pubmed-article:8413180 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8413180 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8413180 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8413180 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8413180 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8413180 | pubmed:issn | 0026-8925 | lld:pubmed |
| pubmed-article:8413180 | pubmed:author | pubmed-author:TanakaKK | lld:pubmed |
| pubmed-article:8413180 | pubmed:author | pubmed-author:Toh-eAA | lld:pubmed |
| pubmed-article:8413180 | pubmed:author | pubmed-author:MatsuoSS | lld:pubmed |
| pubmed-article:8413180 | pubmed:author | pubmed-author:KawakamiKK | lld:pubmed |
| pubmed-article:8413180 | pubmed:author | pubmed-author:ShirayamaMM | lld:pubmed |
| pubmed-article:8413180 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8413180 | pubmed:volume | 240 | lld:pubmed |
| pubmed-article:8413180 | pubmed:geneSymbol | MSI3 | lld:pubmed |
| pubmed-article:8413180 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8413180 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8413180 | pubmed:pagination | 323-32 | lld:pubmed |
| pubmed-article:8413180 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8413180 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8413180 | pubmed:articleTitle | MSI3, a multicopy suppressor of mutants hyperactivated in the RAS-cAMP pathway, encodes a novel HSP70 protein of Saccharomyces cerevisiae. | lld:pubmed |
| pubmed-article:8413180 | pubmed:affiliation | Department of Biology, Faculty of Science, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:8413180 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8413180 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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