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rdf:type |
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lifeskim:mentions |
umls-concept:C0008669,
umls-concept:C0012854,
umls-concept:C0023745,
umls-concept:C0039290,
umls-concept:C0086418,
umls-concept:C0162789,
umls-concept:C0205250,
umls-concept:C0205352,
umls-concept:C0378073,
umls-concept:C0475264,
umls-concept:C1335671,
umls-concept:C1521533,
umls-concept:C1521913,
umls-concept:C1882417,
umls-concept:C2745888
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pubmed:issue |
8
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pubmed:dateCreated |
1993-8-12
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pubmed:databankReference |
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pubmed:abstractText |
Glucagon-like peptide-1 is a fragment of proglucagon secreted by intestinal L-cells. It has potent glucose-dependent insulin secretory effects and also suppresses gastric acid secretion in the stomach. The biological actions of GLP-1 are mediated by the GLP-1 receptor, the structure of which has recently been determined. Defects in insulin secretion are a common feature of NIDDM and as such the GLP-1 receptor is a candidate for contributing to the development of this clinically and genetically heterogeneous disorder. As a first step in determining the role of the GLP-1 receptor in the development of NIDDM, we have isolated the human GLP-1 receptor gene and mapped it to chromosome 6, band p21.1, using the technique of fluorescence in situ hybridization. We also identified a simple tandem repeat DNA polymorphism in the human GLP-1 receptor gene of the form (TG)n. This DNA polymorphism has 14 alleles and a heterozygosity of > 0.8. We have used this DNA polymorphism to localize the GLP-1 receptor gene within the genetic map of the short arm of chromosome 6. This DNA polymorphism will facilitate genetic studies of the contribution of the GLP-1 receptor gene to impaired beta-cell function and NIDDM.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:geneSymbol |
GLP1R
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1215-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8392011-Base Sequence,
pubmed-meshheading:8392011-Chromosome Mapping,
pubmed-meshheading:8392011-Chromosomes, Human, Pair 6,
pubmed-meshheading:8392011-DNA,
pubmed-meshheading:8392011-Genetic Linkage,
pubmed-meshheading:8392011-Humans,
pubmed-meshheading:8392011-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8392011-Lod Score,
pubmed-meshheading:8392011-Molecular Sequence Data,
pubmed-meshheading:8392011-Polymorphism, Genetic,
pubmed-meshheading:8392011-Receptors, Cell Surface,
pubmed-meshheading:8392011-Receptors, Glucagon,
pubmed-meshheading:8392011-Repetitive Sequences, Nucleic Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of Chicago, Illinois.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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