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| pubmed-article:8386508 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
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| pubmed-article:8386508 | lifeskim:mentions | umls-concept:C1335867 | lld:lifeskim |
| pubmed-article:8386508 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:8386508 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:8386508 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8386508 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:8386508 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8386508 | pubmed:dateCreated | 1993-5-20 | lld:pubmed |
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| pubmed-article:8386508 | pubmed:abstractText | The rodent SSTR2 mRNA has been reported to be alternatively spliced to generate long (SSTR2A) and short (SSTR2B) receptor isoforms which differ in sequence at their C-terminal regulatory domains. By extending the 3' nucleotide sequence of the human gene (hSSTR2) we show highly conserved intron/exon boundaries suggesting that hSSTR2 is also capable of generating spliced variants. mRNA blots of rat tissues reveal 2 transcripts of 2.8 and 2.3 kb that are differentially expressed in brain regions and multiple peripheral organs. The 2.3 kb mRNA is preferentially expressed in pituitary tumor cells (AtT-20 mouse, GH3 rat, human prolactinoma, human somatotroph adenoma), but not in rat or human insulinoma cells. This transcript shows 4 fold induction by forskolin in AtT-20 cells suggesting cAMP dependent control of SSTR2 gene expression. The abundant expression of SSTR2 gene, the occurrence of 2 isoforms and evidence of extensive regulation at both gene and peptide levels, suggests that SSTR2 is the principal SST-14 selective subtype. | lld:pubmed |
| pubmed-article:8386508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8386508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8386508 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8386508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8386508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8386508 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8386508 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8386508 | pubmed:author | pubmed-author:PatelY CYC | lld:pubmed |
| pubmed-article:8386508 | pubmed:author | pubmed-author:KentGG | lld:pubmed |
| pubmed-article:8386508 | pubmed:author | pubmed-author:SrikantC BCB | lld:pubmed |
| pubmed-article:8386508 | pubmed:author | pubmed-author:GreenwoodMM | lld:pubmed |
| pubmed-article:8386508 | pubmed:author | pubmed-author:PanettaRR | lld:pubmed |
| pubmed-article:8386508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8386508 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8386508 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:8386508 | pubmed:geneSymbol | SSTR2 | lld:pubmed |
| pubmed-article:8386508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8386508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8386508 | pubmed:pagination | 288-94 | lld:pubmed |
| pubmed-article:8386508 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8386508 | pubmed:meshHeading | pubmed-meshheading:8386508-... | lld:pubmed |
| pubmed-article:8386508 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8386508 | pubmed:articleTitle | Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. | lld:pubmed |
| pubmed-article:8386508 | pubmed:affiliation | Fraser Laboratories, Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada. | lld:pubmed |
| pubmed-article:8386508 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8386508 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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