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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1993-5-20
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pubmed:abstractText |
In 14 in situ canine renal transplants, intracellular phosphorus metabolites were evaluated by phosphorus-31 magnetic resonance spectroscopy (31P-MRS), performed using surface coils to investigate the usefulness of this technique for assessing renal viability in situ. Group I control kidneys (n = 5) were autografts, as were Group II (n = 5) kidneys: the latter group were subjected to surgically induced vascular ischemia and thrombosis. Group III kidneys (n = 4) were rejecting allografts. Renal flow and function, as measured by 99mTc-DTPA, and findings on histologic examination were correlated with 31P-MRS spectra. Group I kidneys showed excellent viability on both 99mTc-DTPA studies and biopsy evaluation, and their 31P-MRS-derived ratios of phosphomonoesters/inorganic phosphate (PME/Pi) and adenosine triphosphate/Pi (ATP/Pi) were high (1.32 +/- 0.23 and 0.90 +/- 0.36, respectively). In contrast, Group II kidneys demonstrated poor flow and function, histologic evidence of severe ischemia from venous and arterial thrombosis, and significantly (P < 0.005) less viability than controls, as monitored by 31P-MRS PME/Pi (0.58 +/- 0.30) and ATP/Pi (0.20 +/- 0.13) ratios. Group III kidneys also demonstrated poor flow and function with 99mTc-DTPA, and the associated histologically injury was noted to be caused by accelerated rejection and severe vascular damage. PME/Pi (0.24 +/- 0.22) and ATP/Pi (0.10 +/- 0.01) ratios were also significantly (P < 0.005) less than those in controls, reflecting nonviability. The 31P-MRS-derived PME/Pi and ATP/Pi ratios enable a qualitative noninvasive assessment of blood flow-dependent renal viability, but with currently used localization techniques the differentiation between severe ischemia and severe acute rejection was not possible.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Organotechnetium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Succimer,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m...,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m Pentetate
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-1348
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8386489-Adenosine Triphosphate,
pubmed-meshheading:8386489-Animals,
pubmed-meshheading:8386489-Dogs,
pubmed-meshheading:8386489-Graft Rejection,
pubmed-meshheading:8386489-Graft Survival,
pubmed-meshheading:8386489-Kidney,
pubmed-meshheading:8386489-Kidney Transplantation,
pubmed-meshheading:8386489-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8386489-Organotechnetium Compounds,
pubmed-meshheading:8386489-Phosphates,
pubmed-meshheading:8386489-Renal Artery Obstruction,
pubmed-meshheading:8386489-Succimer,
pubmed-meshheading:8386489-Technetium Tc 99m Dimercaptosuccinic Acid,
pubmed-meshheading:8386489-Technetium Tc 99m Pentetate,
pubmed-meshheading:8386489-Thrombosis
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pubmed:year |
1993
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pubmed:articleTitle |
Assessment of in situ renal transplant viability by 31P-MRS: experimental study in canines.
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pubmed:affiliation |
Department of Urology, University of California School of Medicine, San Francisco.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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