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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1993-5-14
|
| pubmed:abstractText |
The prevalence of human papillomavirus (HPV) genotypes in relation to age was investigated by the polymerase chain reaction (PCR) method in cytologically normal smears from 4 different groups of women. Group A consisted of young women from a district population, aged 15-34 years, using oral contraceptives and visiting general practitioners for a check-up (n = 156); group B were asymptomatic women, aged 35-55, in a district population participating in a triennial screening program for cervical cancer (n = 1555); group C and D consisted of women, seen at the gynecological outpatient department for a wide spectrum of gynecological complaints or for control of their hormonal contraception, aged 15-34 years (n = 2320), and aged 35-55 years (n = 1826) respectively. An HPV (all types) prevalence of 14.1%, 4.1%, 13.9% and 6.6% and an HPV 16/18 prevalence of 3.8%, 0.9%, 3.3% and 1.5% were found in groups A, B, C and D respectively. Statistically significant differences (p value < 0.001) in HPV prevalence were found between women aged 15-34 years and women aged 35-55 years in the district population and in the hospital population. No statistically significant differences in HPV 16/18 were observed after age-matching between women in corresponding age-classes of both populations. In a 5-year interval analysis a strong age-dependent relationship was demonstrated, with a maximum between 20 and 24 years. After the age of 35 a constant level of 1-2% HPV 16/18 was observed. These results indicate that genital HPV infections are age-dependent and suggest that HPV infections at young age can be transient. The implications of these findings in the context of cervical cancer screening are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
919-23
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:8386137-Adolescent,
pubmed-meshheading:8386137-Adult,
pubmed-meshheading:8386137-Age Factors,
pubmed-meshheading:8386137-Aging,
pubmed-meshheading:8386137-Cervix Uteri,
pubmed-meshheading:8386137-Family Practice,
pubmed-meshheading:8386137-Female,
pubmed-meshheading:8386137-Genotype,
pubmed-meshheading:8386137-Hospitals, General,
pubmed-meshheading:8386137-Humans,
pubmed-meshheading:8386137-Middle Aged,
pubmed-meshheading:8386137-Papillomaviridae,
pubmed-meshheading:8386137-Polymerase Chain Reaction,
pubmed-meshheading:8386137-Prevalence,
pubmed-meshheading:8386137-Suburban Population,
pubmed-meshheading:8386137-Tumor Virus Infections,
pubmed-meshheading:8386137-Urban Population,
pubmed-meshheading:8386137-Uterine Cervical Diseases,
pubmed-meshheading:8386137-Vaginal Smears
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Prevalence of HPV in cytomorphologically normal cervical smears, as determined by the polymerase chain reaction, is age-dependent.
|
| pubmed:affiliation |
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|