Linked Life Data

8355197

Source:http://linkedlifedata.com/resource/pubmed/id/8355197

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-9-17
pubmed:abstractText
The current study was performed to investigate the effects of a 2-week treatment regimen with either hydralazine or the nonpeptide angiotensin II subtype 1 receptor antagonist losartan (both at 10 mg/kg daily s.c. injection) on blood pressure and vascular smooth muscle function and structure in male spontaneously hypertensive rats with established hypertension (24 weeks of age; systolic blood pressure = 174 +/- 7 mm Hg). Systolic blood pressure and body weight were recorded before and once weekly after initiation of treatment. Mean arterial pressure, heart rate and heart weight were determined and experiments were conducted to assess changes in vascular reactivity and arterial medial thickness in ring segments of aorta and tail artery at the end of the treatment period. Systolic blood pressure, as well as mean arterial pressure, were significantly decreased to normotensive levels in hypertensive rats after 2 weeks of either hydralazine or losartan treatment. No effect on heart rate was observed in response to either antihypertensive agent. Body weight was not affected in either of the treatment groups, but a significant decrease in artery ring weight, arterial medial thickness and heart weight was seen only in losartan-treated rats. Whereas no changes in vascular reactivity were seen in hypertensive rats receiving hydralazine, norepinephrine- and serotonin-induced contractions were attenuated and acetylcholine-induced relaxations were enhanced in the losartan-treated rats. These data demonstrate that, although short-term 2-week treatment with either hydralazine or losartan results in normalization of blood pressure, only losartan resulted in significant alterations in vascular function and structure in spontaneously hypertensive rats.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
266
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
642-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Alterations in vascular structure and function after short-term losartan treatment in spontaneously hypertensive rats.
pubmed:affiliation
Division of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Kentucky, Lexington.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't