Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-9-23
pubmed:abstractText
We have treated 40 patients was relapsed or resistant lymphoma with the combination of Etoposide, Prednisolone, Ifosfamide and Cisplatin (EPIC). Complete response was obtained in 11 patients (28%) with an overall response of 58%. The presence of bulky disease (P < 0.005), elevated LDH serum levels (P < 0.005), response to prior chemotherapy (P < 0.01) and B symptoms (P < 0.005) were significantly associated with response. However on multivariate analysis only the presence of bulky disease and of B symptoms were independent adverse factors for response and for survival. The regimen was well tolerated with myelosuppression being the most common toxicity. Leucopenia < or 1,000 microliters-1 and thrombocytopenia < or = 25,000 microliters-1 developed in 27% and 4% of cycles respectively. There were no treatment related deaths. The EPIC regimen has equivalent activity to other reported cisplatin based regimens used in the treatment of recurrent lymphoma, but is associated with lower treatment related morbidity and mortality.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-1021234, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-1670642, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-1710655, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-1999711, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2043497, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2043500, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2251518, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2251520, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2302456, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2420012, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2446751, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2453619, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2909663, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-291480, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-2993535, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3013401, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3041598, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3041599, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3180059, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3289942, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3295541, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3295542, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3305793, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3334893, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-350386, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3559649, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3567972, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3572465, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3607781, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-3819806, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-387221, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-4039530, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-4039635, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-4760525, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6197916, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6330613, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6366124, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6414693, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6538808, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6627240, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6681731, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-6761864, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7004634, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7016324, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7083459, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7104493, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7127334, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7197582, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7198012, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-7459811, http://linkedlifedata.com/resource/pubmed/commentcorrection/8353050-831755
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
599-604
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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