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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1993-8-17
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pubmed:abstractText |
The expression of fragile sites induced by aphidicolin (APC) was evaluated on metaphase chromosomes obtained from the peripheral blood lymphocytes of 26 women with breast cancer and 15 sex- and age-matched normal controls. Both the proportion of damaged cells (P < 0.001) and the mean number of gaps and breaks per cell (0.02 < P < 0.05) were significantly higher in the patient group. There were no differences in either the age-related fragile site levels or the expression of single fragile sites between patients and controls. Our findings indicate an increased genetic instability in women with breast carcinoma.
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pubmed:commentsCorrections | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0165-4608
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8330266-Adult,
pubmed-meshheading:8330266-Age Factors,
pubmed-meshheading:8330266-Aged,
pubmed-meshheading:8330266-Aphidicolin,
pubmed-meshheading:8330266-Breast Neoplasms,
pubmed-meshheading:8330266-Cells, Cultured,
pubmed-meshheading:8330266-Chromosome Fragile Sites,
pubmed-meshheading:8330266-Chromosome Fragility,
pubmed-meshheading:8330266-Female,
pubmed-meshheading:8330266-Humans,
pubmed-meshheading:8330266-Lymphocytes,
pubmed-meshheading:8330266-Middle Aged
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pubmed:year |
1993
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pubmed:articleTitle |
Expression of aphidicolin-induced fragile sites in lymphocytes of patients with breast cancer.
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pubmed:affiliation |
Istituto di Clinica Medica I, Università di Perugia, Italy.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|